In Vivo Analysis of Angle Dysgenesis in Primary Congenital, Juvenile, and Adult-Onset Open Angle Glaucoma.

Gupta, Viney, Chaurasia, Abadh K, Gupta, Shikha, Gorimanipalli, Bhavya, Sharma, Ajay and Gupta, Amisha (2017) In Vivo Analysis of Angle Dysgenesis in Primary Congenital, Juvenile, and Adult-Onset Open Angle Glaucoma. Investigative ophthalmology & visual science, 58 (13). pp. 6000-6005.

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Official URL: http://dx.doi.org/10.1167/iovs.17-22695

Abstract

<h4>Purpose</h4>The purpose of this study was to comparatively evaluate angle dysgenesis in vivo, among congenital, juvenile, and adult-onset open angle glaucoma patients.<h4>Methods</h4>A cross-sectional evaluation of 96 glaucoma patients, 22 children with primary congenital glaucoma (PCG) old enough to cooperate for optical coherence tomography (OCT), 34 juvenile-onset open angle glaucoma (JOAG) patients, 40 adult-onset primary open angle glaucoma (POAG), and 30 healthy subjects, was carried out using high-resolution anterior segment spectral domain (SD)-OCT. Subgroup analysis was done for presence/ absence of angle dysgenesis as defined by presence of abnormal tissue/hyperreflective membrane within angle recess and/or absence of Schlemm's canal (SC).<h4>Results</h4>Morphologic features suggestive of angle dysgenesis such as the presence of abnormal tissue at the angle and a hyperreflective membranous structure covering the meshwork were seen in all PCG eyes (100%), in 14 (40%) JOAG eyes, and none of the POAG eyes in comparison to healthy eyes (P = 0.01, P = 0.03, and P = 0.23 for PCG, JOAG, and POAG, respectively). SC could be seen in 27 (90%) healthy eyes compared with only 7 (30%) in PCG (P = 0.01) 20 (60%) JOAG eyes (P = 0.03), and 26 (65%) adult-onset POAG eyes (P = 0.23; χ2 test).<h4>Conclusions</h4>Angle dysgenesis in the form of abnormal tissue at the angle/hyperreflective membrane and/or absence of SC could be identified on anterior segment SD-OCT, which can be used for in vivo evaluation of eyes with developmental glaucoma.

Item Type:	Article
Uncontrolled Keywords:	Optic Nerve, Humans, Optic Nerve Diseases, Glaucoma, Open-Angle, Tomography, Optical Coherence, Case-Control Studies, Cross-Sectional Studies, Adolescent, Adult, Child, Female, Male, Young Adult
Depositing User:	Symplectic Admin
Date Deposited:	15 May 2019 09:26
Last Modified:	05 Feb 2024 22:50
DOI:	10.1167/iovs.17-22695
Open Access URL:	http://doi.org/10.1167/iovs.17-22695
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3041419