Intranasal melanoma treated with radiation therapy in three dogs

Davies, Owen, Spencer, Sarah, Necova, Slavomira, Holmes, Emma, Taylor, Angela, Blackwood, Laura and Lara-Garcia, Ana (2017) Intranasal melanoma treated with radiation therapy in three dogs. VETERINARY QUARTERLY, 37 (1). pp. 274-281.

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Official URL: http://dx.doi.org/10.1080/01652176.2017.1387828

Abstract

Three dogs were investigated for chronic unilateral nasal discharge. In all cases CT imaging showed an intranasal mass causing turbinate lysis and no evidence of metastasis. Cytology in cases 1 (a 14-year-old neutered male crossbreed dog) and 2 (a five-year-old neutered male German Shepherd dog) demonstrated a pleomorphic cell population with variable intracellular pigment suspicious of melanocytic neoplasia. Histopathology with immunohistochemistry (Melan-A and vimentin, plus PNL-2 in one case) confirmed the diagnosis of melanoma in all dogs. All dogs were treated with megavoltage radiotherapy using linear accelerators. Cases 1 and 3 (a nine-year-old neutered female beagle dog) received a hypofractionated (4 × 8 Gy) protocol and case 2 received a definitive (12 × 4 Gy) protocol. Complete remission was demonstrated on repeat CT scan five months after diagnosis in case 1 and seven months in case 2. Stable disease was documented on CT at four months for case 3; however, clinical signs in this dog remained controlled for 10 months in total. Case 1 died of unrelated causes five months after diagnosis, case 2 was euthanased due to the development of seizures 13 months after diagnosis, and case 3 was lost to follow-up 12 months after diagnosis. Melanoma should be considered as a rare differential diagnosis for primary nasal neoplasia in the dog and radiation therapy can be used as effective local therapy.

Item Type:	Article
Uncontrolled Keywords:	Dog, canine, nasal, cancer, melanoma, radiotherapy
Depositing User:	Symplectic Admin
Date Deposited:	15 May 2019 09:46
Last Modified:	19 Jan 2023 00:45
DOI:	10.1080/01652176.2017.1387828
Open Access URL:	http://doi.org/10.1080/01652176.2017.1387828
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3041433