The relationship of early recurrence of atrial fibrillation and the 3-month integrity of the ablation lesion set

Mujovic, Nebojsa, Marinkovic, Milan, Markovic, Nebojsa, Vucicevic, Vera, Lip, Gregory YH ORCID: 0000-0002-7566-1626, Bunch, T Jared and Potpara, Tatjana S (2018) The relationship of early recurrence of atrial fibrillation and the 3-month integrity of the ablation lesion set. SCIENTIFIC REPORTS, 8 (1). 9875-.

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Official URL: http://dx.doi.org/10.1038/s41598-018-28072-y

Abstract

Early recurrence of atrial fibrillation (ERAF) after catheter-ablation (CA) can be a transient phenomenon due to inflammation, or a harbinger of late AF recurrence due to CA lesion (re)conduction. We studied the relationship between ERAF and the 3-month CA lesions integrity. Forty one consecutive AF patients who underwent a pulmonary vein isolation (PVI), roof line (RL) and mitral isthmus line (MIL) CA were enrolled. At 3 months all patients underwent invasive assessment of the lesion set integrity irrespective of ERAF. The PVI, RL and MIL ablation was successful in 100.0%, 95.1% and 82.9% patients, respectively. At the 3-month remapping, a gap in PVI-lesion(s), RL or MIL was identified in 61.0%, 31.7% and 36.6% patients, respectively. Patients with (n = 17, 41.5%) compared to those without ERAF (n = 24) had a significantly higher rate of any PV-reconnection (88.2% vs. 41.7%), the right PV(s)-reconnection (82.5% vs. 29.2%) and the RL gap (52.9% vs. 16.7%), as well as a higher number of reconnected right PVI-segments, all p < 0.05. On multivariate analysis, only the number of reconnected right PVI-segments was associated with ERAF (OR 4.26, p = 0.004). The ERAF following PVI + RL + MIL ablation was significantly related to 3-month PV-reconnections and the presence of RL gaps.

Item Type:	Article
Uncontrolled Keywords:	Humans, Atrial Fibrillation, Recurrence, Catheter Ablation, Treatment Outcome, Follow-Up Studies, Time Factors, Middle Aged, Female, Male
Depositing User:	Symplectic Admin
Date Deposited:	17 May 2019 10:27
Last Modified:	19 Jan 2023 00:45
DOI:	10.1038/s41598-018-28072-y
Open Access URL:	http://doi.org/10.1038/s41598-018-28072-y
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3041759