Apomorphine in the treatment of Parkinson's disease: a review

Pessoa, Renata Ramina, Moro, Adriana, Munhoz, Renato Puppi, Teive, Helio AG and Lees, Andrew J ORCID: 0000-0002-2476-4385 (2018) Apomorphine in the treatment of Parkinson's disease: a review. ARQUIVOS DE NEURO-PSIQUIATRIA, 76 (12). pp. 840-848.

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Abstract

Optimizing idiopathic Parkinson's disease treatment is a challenging, multifaceted and continuous process with direct impact on patients' quality of life. The basic tenet of this task entails tailored therapy, allowing for optimal motor function with the fewest adverse effects. Apomorphine, a dopamine agonist used as rescue therapy for patients with motor fluctuations, with potential positive effects on nonmotor symptoms, is the only antiparkinsonian agent whose capacity to control motor symptoms is comparable to that of levodopa. Subcutaneous administration, either as an intermittent injection or as continuous infusion, appears to be the most effective and tolerable route. This review summarizes the historical background, structure, mechanism of action, indications, contraindications and side effects, compares apomorphine infusion therapy with other treatments, such as oral therapy, deep brain stimulation and continuous enteral infusion of levodopa/carbidopa gel, and gives practical instructions on how to initiate treatment.

Item Type:	Article
Additional Information:	publicationstatus: published
Uncontrolled Keywords:	Apomorphine, dopaminer agents, Parkinsons disease, review
Depositing User:	Symplectic Admin
Date Deposited:	17 May 2019 10:45
Last Modified:	19 Jan 2023 00:45
DOI:	10.1590/0004-282X20180140
Open Access URL:	http://dx.doi.org/10.1590/0004-282x20180140
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3041761