Martin, Glen P, Sperrin, Matthew, Ludman, Peter F, de Belder, Mark A, Redwood, Simon R, Townend, Jonathan N, Gunning, Mark, Moat, Neil E, Banning, Adrian P, Buchan, Iain 
ORCID: 0000-0003-3392-1650 et al (show 1 more authors)
(2018)
Novel United Kingdom prognostic model for 30-day mortality following transcatheter aortic valve implantation.
HEART, 104 (13).
pp. 1109-1116.
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Novel United Kingdom prognostic model for 30-day mortality following transcatheter aortic valve implantation.pdf - Published version Download (2MB) | Preview |
Abstract
<h4>Objective</h4>Existing clinical prediction models (CPM) for short-term mortality after transcatheter aortic valve implantation (TAVI) have limited applicability in the UK due to moderate predictive performance and inconsistent recording practices across registries. The aim of this study was to derive a UK-TAVI CPM to predict 30-day mortality risk for benchmarking purposes.<h4>Methods</h4>A two-step modelling strategy was undertaken: first, data from the UK-TAVI Registry between 2009 and 2014 were used to develop a multivariable logistic regression CPM using backwards stepwise regression. Second, model-updating techniques were applied using the 2013-2014 data, thereby leveraging new approaches to include frailty and to ensure the model was reflective of contemporary practice. Internal validation was performed by bootstrapping to estimate in-sample optimism-corrected performance.<h4>Results</h4>Between 2009 and 2014, up to 6339 patients were included across 34 centres in the UK-TAVI Registry (mean age, 81.3; 2927 female (46.2%)). The observed 30-day mortality rate was 5.14%. The final UK-TAVI CPM included 15 risk factors, which included two variables associated with frailty. After correction for in-sample optimism, the model was well calibrated, with a calibration intercept of 0.02 (95% CI -0.17 to 0.20) and calibration slope of 0.79 (95% CI 0.55 to 1.03). The area under the receiver operating characteristic curve, after adjustment for in-sample optimism, was 0.66.<h4>Conclusion</h4>The UK-TAVI CPM demonstrated strong calibration and moderate discrimination in UK-TAVI patients. This model shows potential for benchmarking, but even the inclusion of frailty did not overcome the need for more wide-ranging data and other outcomes might usefully be explored.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Humans, Aortic Valve Stenosis, Treatment Outcome, Registries, Risk Assessment, Risk Factors, Reproducibility of Results, Predictive Value of Tests, Decision Support Techniques, Time Factors, Adult, Aged, Aged, 80 and over, Middle Aged, Benchmarking, Quality Indicators, Health Care, Female, Male, Transcatheter Aortic Valve Replacement, United Kingdom |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 31 May 2019 09:09 |
| Last Modified: | 19 Jan 2023 00:42 |
| DOI: | 10.1136/heartjnl-2017-312489 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3043794 |
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