Peripheral trauma and risk of dystonia: What are the evidences and potential co-risk factors from a population insurance database?

Macerollo, Antonella ORCID: 0000-0003-4322-2706, Edwards, Mark J, Huang, Hui-Chun, Lu, Ming-Kuei, Chen, Hsuan-Ju, Tsai, Chon-Haw and Chen, Jui Cheng (2019) Peripheral trauma and risk of dystonia: What are the evidences and potential co-risk factors from a population insurance database? PLOS ONE, 14 (5). e0216772-.

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Official URL: http://dx.doi.org/10.1371/journal.pone.0216772

Abstract

<h4>Background</h4>Dystonia is a neurological syndrome typically resulting in abnormal postures.<h4>Objectives</h4>We tested the role of physical injury as potential risk factor for development of dystonia using The National Health Insurance Research Database of Taiwan.<h4>Methods</h4>We identified 65704 people who were coded in the database as having had peripheral traumatic injuries (ICD-9-CM 807-848 and 860-959) in the year 2000. Patients with traumatic brain or spine injuries were excluded from analysis. We matched them using purposive sampling with 65704 people in the database who had not suffered peripheral trauma. We looked then at the incidence of dystonia occurring at least 1 year from the date of the peripheral trauma until 2011. Psychiatric symptoms (depression and anxiety) and sleeps difficulties have been investigated as potential covariates.<h4>Results</h4>We found 189 patients with dystonia (0.28%) in the trauma group, and 52 patients with dystonia (0.08%) in the non-trauma group. Trauma was independently associated with dystonia (adjusted HR = 3.12, 95% CI = 2.30-4.24). The incidence density of dystonia in the trauma group was 2.27 per 10000 person-years, while it was 0.71 per 10000 person-years in the non-trauma group Beyond the peripheral trauma, other variables associated to the incidence of dystonia included female sex, aged 40 years and above, depression and sleep disorders.<h4>Conclusion</h4>These data from a large population dataset support traumatic injury as a risk factor for the development of dystonia.

Item Type:	Article
Uncontrolled Keywords:	Humans, Dystonic Disorders, Wounds and Injuries, Incidence, Risk Factors, Retrospective Studies, Databases, Factual, Adult, Middle Aged, Insurance, Health, Female, Male, Young Adult
Depositing User:	Symplectic Admin
Date Deposited:	31 May 2019 10:25
Last Modified:	19 Jan 2023 00:41
DOI:	10.1371/journal.pone.0216772
Open Access URL:	https://doi.org/10.1371/journal.pone.0216772
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3043829