Højen, AA, Søgaard, M, Melgaard, L, Lane, DA 
ORCID: 0000-0002-5604-9378, Sørensen, EE, Goldhaber, SZ and Larsen, TB
(2019)
Psychotropic drug use following venous thromboembolism versus diabetes mellitus in adolescence or young adulthood: A Danish nationwide cohort study.
BMJ Open, 9 (5).
e026159-.
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Abstract
© Author(s) (or their employer(s)) 2018. Objectives Critical and chronic illness in youth such as diabetes can lead to impaired mental health. Despite the potentially traumatic and life-Threatening nature of venous thromboembolism (VTE), the long-Term mental health of adolescents and young adults with VTE is unclear. We compared the long-Term mental health of adolescents and young adults with VTE versus adolescents and young adults with insulin-dependent diabetes mellitus (IDDM) using psychotropic drug purchase as proxy for mental health. Design Nationwide registry-based cohort study. Setting Denmark 1997-2015. Participants All patients aged 13-33 years with an incident diagnosis of VTE (n=5065) or IDDM (n=6609). Exposure First time primary hospital diagnosis of VTE or IDDM. Primary and secondary outcome measures Adjusted absolute risk and risk difference at 1 and 5 years follow-up for first psychotropic drug purchase comparing patients with VTE and patients with IDDM. Results The absolute 1 year risk of psychotropic drug use was 6.2% among VTE patients versus 3.6% among patients with IDDM, at 5 years this was 19.3%-14.7%, respectively. After adjusting for the effect of sex, age and risk factors for VTE this corresponded to a 1 year risk differences of 1.9% (95 % CI 0.1% to 3.3%). At 5 years follow-up the risk difference was 1.9% (95% CI 0.5% to 3.3%). Conclusion One-fifth of adolescents and young adults with incident VTE had claimed a prescription for a psychotropic drug within 5 years, a risk comparable to that of young patients with IDDM.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | adolescents, diabetes, embolism and thrombosis, psychology, venous thromboembolism, young adult, Adolescent, Adult, Denmark, Diabetes Mellitus, Type 1, Female, Humans, Longitudinal Studies, Male, Mental Disorders, Psychotropic Drugs, Registries, Risk Factors, Venous Thromboembolism, Young Adult |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 04 Jun 2019 08:51 |
| Last Modified: | 19 Jan 2023 00:41 |
| DOI: | 10.1136/bmjopen-2018-026159 |
| Open Access URL: | http://doi.org/10.1136/bmjopen-2018-026159 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3044354 |
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