Expression of VEGFR and PDGFR-α/-β in 187 canine nasal carcinomas

Gramer, I, Killick, D ORCID: 0000-0002-8787-7651, Scase, T, Chandry, D, Marrington, M and Blackwood, L (2017) Expression of VEGFR and PDGFR-α/-β in 187 canine nasal carcinomas. VETERINARY AND COMPARATIVE ONCOLOGY, 15 (3). pp. 1041-1050.

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Official URL: http://dx.doi.org/10.1111/vco.12245

Abstract

Radiotherapy represents the standard of care for intranasal carcinomas. Responses to tyrosine kinase inhibitors (TKIs) have been reported but data on expression of target receptor tyrosine kinases (rTKs) is limited. This study characterizes the expression of vascular endothelial growth factor receptor (VEGFR), platelet-derived growth factor receptor (PDGFR)-α and PDGFR-β in canine intranasal carcinomas. Histological samples from 187 dogs were retrieved. Immunohistochemistry was performed using commercially available antibodies. Expression of rTKs was classified into weak, moderate or intense and additionally recorded as cytoplasmic, membranous, cytoplasmic-membranous, nuclear or stromal. VEGFR was expressed in 158 dogs with predominantly moderate expression (36.9%) and a cytoplasmic-membranous expression pattern (70.9%). PDGFR-α was detected in 133 with predominantly weak expression (57.9%) and cytoplasmic pattern (87.9%). PDGFR-β was identified in 74 patients with a predominantly moderate expression (17.6%) and cytoplasmic expression pattern (63.5%). Co-expression of rTKs was common. These results confirm expression of VEGFR, PDGFR-α and PDGFR-β in canine intranasal carcinomas and support the utility of TKIs.

Item Type:	Article
Uncontrolled Keywords:	dog, nasal carcinoma, PDGFR-alpha, PDGFR-beta, TKI, VEGFR
Depositing User:	Symplectic Admin
Date Deposited:	05 Aug 2019 15:31
Last Modified:	13 Oct 2023 08:06
DOI:	10.1111/vco.12245
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3050873