Entradas, TJ
(2019)
Photogeneration of singlet oxygen by gold nanoparticles.
PhD thesis, University of Liverpool.
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Abstract
Photodynamic medicine has been known for more than 5000 years when Egyptians, Chinese and Indians used sunlight in combination with some “magic” plants to treat various disorders. Contemporary photodynamic therapy began in the 1900s, received its revival in 1970 due to hematoporphyrin derivative (HpD), and it is now an FDA approved therapeutic option for skin, early lung, and advanced oesophagal cancer in several countries. Although a few photosensitisers have been approved for clinical use, they suffer from several drawbacks such as biological and light instability and lack specificity toward specific types of cells. In this thesis work, we propose plasmonic gold nanoparticles as photosensitisers to overcome the drawbacks of first- and second-generation photosensitiser and investigate their 1O2 photogeneration efficiency upon CW-laser irradiation at their surface plasmon resonance. First, the singlet oxygen sensitivity of two molecular probes (ABDA and DPBF) in different solvent systems was determined, using Rose Bengal as a photosensitiser. Second, we showed conclusively, for the first time, that gold nanoparticles photogenerate 1O2, and that the quantum yield is extremely small. Lastly, gold nanoparticles were functionalized with bovine serum albumin, and their singlet oxygen quantum yield re-evaluated. Our irradiation results showed that the protein corona, i.e. bovine serum albumin, did not affect the 1O2 production.
| Item Type: | Thesis (PhD) |
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| Depositing User: | Symplectic Admin |
| Date Deposited: | 08 Oct 2019 15:55 |
| Last Modified: | 19 Jan 2023 00:25 |
| DOI: | 10.17638/03056575 |
| Supervisors: |
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| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3056575 |
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