Echevarria, Juan E, Banyard, Ashley C, McElhinney, Lorraine M 
ORCID: 0000-0002-6022-348X and Fooks, Anthony R
(2019)
Current Rabies Vaccines Do Not Confer Protective Immunity against Divergent Lyssaviruses Circulating in Europe.
VIRUSES-BASEL, 11 (10).
E892-.
Abstract
The use of the rabies vaccine for post-exposure prophylaxis started as early as 1885, revealing a safe and efficient tool to prevent human rabies cases. Preventive vaccination is the basis for the control of canine-mediated rabies, which has already been eliminated from extensive parts of the world, including Europe. Plans to eliminate canine-mediated human rabies by 2030 have been agreed upon by international organisations. However, rabies vaccines are not efficacious against some divergent lyssaviruses. The presence in European indigenous bats of recently described lyssaviruses, which are not neutralised by antibody responses to existing vaccines, as well as the declaration of an imported case of an African lyssavirus, which also escapes vaccine-derived protection, leaves the European health authorities unable to provide efficacious protective vaccines to some potential situations of human exposure. All these circumstances highlight the need for a universal pan-lyssavirus rabies vaccine, able to prevent human rabies in all circumstances.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | rabies, lyssavirus, vaccine, bat |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 02 Oct 2019 09:58 |
| Last Modified: | 19 Jan 2023 00:24 |
| DOI: | 10.3390/v11100892 |
| Open Access URL: | https://doi.org/10.3390/v11100892 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3056692 |
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