Organic Wastes as Feedstocks for Non-Conventional Yeast-Based Bioprocesses

Do, Diem T Hoang, Theron, Chrispian W ORCID: 0000-0002-8522-6417 and Fickers, Patrick (2019) Organic Wastes as Feedstocks for Non-Conventional Yeast-Based Bioprocesses. MICROORGANISMS, 7 (8). E229-.

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Official URL: http://dx.doi.org/10.3390/microorganisms7080229

Abstract

Non-conventional yeasts are efficient cell factories for the synthesis of value-added compounds such as recombinant proteins, intracellular metabolites, and/or metabolic by-products. Most bioprocess, however, are still designed to use pure, ideal sugars, especially glucose. In the quest for the development of more sustainable processes amid concerns over the future availability of resources for the ever-growing global population, the utilization of organic wastes or industrial by-products as feedstocks to support cell growth is a crucial approach. Indeed, vast amounts of industrial and commercial waste simultaneously represent an environmental burden and an important reservoir for recyclable or reusable material. These alternative feedstocks can provide microbial cell factories with the required metabolic building blocks and energy to synthesize value-added compounds, further representing a potential means of reduction of process costs as well. This review highlights recent strategies in this regard, encompassing knowledge on catabolic pathways and metabolic engineering solutions developed to endow cells with the required metabolic capabilities, and the connection of these to the synthesis of value-added compounds. This review focuses primarily, but not exclusively, on <i>Yarrowia lipolytica</i> as a yeast cell factory, owing to its broad range of naturally metabolizable carbon sources, together with its popularity as a non-conventional yeast.

Item Type:	Article
Uncontrolled Keywords:	waste valorization, alternative feedstocks, microbial bioprocesses, value added products, recombinant proteins, yeast biomass, Yarrowia lipolytica
Depositing User:	Symplectic Admin
Date Deposited:	17 Oct 2019 10:03
Last Modified:	20 Oct 2023 08:28
DOI:	10.3390/microorganisms7080229
Open Access URL:	https://doi.org/10.3390/microorganisms7080229
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3058476