Duffy, JMN, Hirsch, M, Ziebland, S, McManus, RJ, Duffy, James MN, Brown, Mark, Gale, Chris, Grobman, William, Fitzpatrick, Ray, Karumanchi, S Ananth et al (show 12 more authors)
(2019)
Methodological decisions influence the identification of potential core outcomes in studies related to pre-eclampsia: an analysis informing the development of recommendations for future core outcome set developers.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 126 (12).
pp. 1482-1490.
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Abstract
<h4>Objective</h4>To quantify the effect of different methodological decisions on the identification of potential core outcomes to inform the development of recommendations for future core coutcome set developers.<h4>Design</h4>Mixed methods study.<h4>Setting</h4>A core outcome set for pre-eclampsia was used as an exemplar.<h4>Sample</h4>A long list of potential core outcomes was developed by undertaking a systematic review of pre-eclampsia trials and performing a thematic analysis of in-depth patient interviews.<h4>Methods</h4>Specific methods used to generate long lists of potential core outcomes were evaluated.<h4>Results</h4>Different methodological decisions had a substantial impact on the identification of potential core outcomes. Extracting outcomes from published pre-eclampsia trials was an effective way of identifying 48 maternal, eight fetal, 25 neonatal outcomes, and eight patient-reported outcomes. Limiting the extraction of outcomes to primary outcomes or outcomes commonly reported in pre-eclampsia trials reduced the number and diversity of potential core outcomes identified. Thematic analysis of in-depth patient interviews ensured an additional five patient reported outcomes and six outcomes related to future child health were identified.<h4>Conclusions</h4>Future core outcome set developers should use quantitative and qualitative methods when developing a long list of potential core outcomes. TWEETABLE ABSTRACT: @OfficialNIHR research published in @BJOGtweets informs new recommendations for future @coreoutcomes developers.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Core outcome sets, outcomes, pre-eclampsia, qualitative interviews, systematic review |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 28 Oct 2019 10:42 |
| Last Modified: | 19 Jan 2023 00:21 |
| DOI: | 10.1111/1471-0528.15892 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3059438 |
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