Does the intra-articular injection of antimicrobials alongside corticosteroids or other medications reduce the risk of synovial sepsis?

Braid, Helen R ORCID: 0000-0003-2582-7584 (2019) Does the intra-articular injection of antimicrobials alongside corticosteroids or other medications reduce the risk of synovial sepsis? Veterinary Evidence, 4 (4).

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Abstract

<jats:p>PICO question&#x0D; In horses, does treatment with intra-articular antimicrobials concurrently with intra-articular corticosteroids reduce the risk of iatrogenic synovial sepsis compared to intra-articular corticosteroids alone?&#x0D; Clinical bottom line&#x0D; From the current literature, there is no evidence showing that intra-articular injection of antibiotics in conjunction with corticosteroids reduces the risk of synovial sepsis. However, the intra-articular injection of polysulphated glycosaminoglycans (PSGAGs) in combination with corticosteroids was noted as a risk factor for developing iatrogenic synovial sepsis and therefore concurrent antibiotic injection when administering PSGAGs may be warranted. The reported frequency of infection following intra-articular injections was very low (0.02–0.08%).  An overall prevalence of iatrogenic synovial sepsis following all intra-articular injections based on data from all included studies was calculated as 0.02% (CI 0.02–0.03%). However, due to the paucity of literature on the topic, further studies are required in this field to determine more accurate clinical recommendations.&#x0D; </jats:p>

Item Type:	Article
Uncontrolled Keywords:	Infectious Diseases, Hematology, Sepsis, Prevention, 6 Evaluation of treatments and therapeutic interventions, 6.1 Pharmaceuticals, Inflammatory and immune system, Infection
Depositing User:	Symplectic Admin
Date Deposited:	05 Nov 2019 09:33
Last Modified:	15 Mar 2024 14:41
DOI:	10.18849/ve.v4i4.194
Related URLs:	Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3060541

Available Versions of this Item

• In horses, does the treatment with intra-articular antimicrobials concurrently with intra-articular corticosteroids reduce the risk of iatrogenic synovial sepsis compared to intra-articular corticosteroids alone? (deposited 21 Aug 2019 08:43)
  • Does the intra-articular injection of antimicrobials alongside corticosteroids or other medications reduce the risk of synovial sepsis? (deposited 05 Nov 2019 09:33) [Currently Displayed]