Marttila, Saara, Chatsirisupachai, Kasit 
ORCID: 0000-0001-9446-6714, Palmer, Daniel and de Magalhaes, Joao Pedro ORCID: 0000-0002-6363-2465
(2020)
Ageing-associated changes in the expression of lncRNAs in human tissues reflect a transcriptional modulation in ageing pathways.
MECHANISMS OF AGEING AND DEVELOPMENT, 185.
111177-.
Abstract
Ageing-associated changes in the protein coding transcriptome have been extensively characterised, but less attention has been paid to the non-coding portion of the human genome, especially to long non-coding RNAs (lncRNAs). Only a minority of known lncRNAs have been functionally characterised; however, a handful of these lncRNAs have already been linked to ageing-associated processes. To gain more information on the effects of ageing on lncRNAs, we identified from GTEx data lncRNAs that show ageing-associated expression patterns (age-lncRNAs) in 29 human tissues in 20-79-year-old individuals. The age-lncRNAs identified were highly tissue-specific, but the protein coding genes co-expressed with the age-lncRNAs and the functional categories associated with the age-lncRNAs showed significant overlap across tissues. Functions associated with the age-lncRNAs, including immune system processes and transcription, were similar to what has previously been reported for protein coding genes with ageing-associated expression pattern. As the tissue-specific age-lncRNAs were associated with shared functions across tissues, they may reflect the tissue-specific fine-tuning of the common ageing-associated processes. The present study can be utilised as a resource when selecting and prioritising lncRNAs for further functional analyses.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Aging, Transcriptomics, lncRNA, ncRNA |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 20 Nov 2019 14:42 |
| Last Modified: | 19 Jan 2023 00:19 |
| DOI: | 10.1016/j.mad.2019.111177 |
| Open Access URL: | https://www.sciencedirect.com/science/article/pii/... |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3062569 |
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