Activation of a TLR9 mediated innate immune response in preeclampsia

Williamson, Rachel D, McCarthy, Fergus P, Kenny, Louise C ORCID: 0000-0002-9011-759X and McCarthy, Cathal M (2019) Activation of a TLR9 mediated innate immune response in preeclampsia. SCIENTIFIC REPORTS, 9 (1). 5920-.

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Official URL: http://dx.doi.org/10.1038/s41598-019-42551-w

Abstract

Preeclampsia is a multisystemic disorder leading to the development of a placental ischemic microenvironment with a resultant increase in oxidative stress. There is evidence that mitochondrial dysfunction and the innate immune system both play a role in the pathophysiology of this disease. Mitochondrial DAMPs such as mtDNA bind specific pattern recognition receptors such as Toll-like receptor 9 (TLR9) on the endosomal surface of immune cells, in particular neutrophils, subsequently activating them and triggering an innate response. We hypothesised that the exaggerated innate immune response seen in preeclampsia is provoked by dysfunctional mitochondria. Here we provide evidence that TLR9 activity is significantly increased at time of disease in women with preeclampsia. Furthermore, we show activation of neutrophil markers, Calprotectin, Myeloperoxidase (MPO), and IL-8 are significantly increased at time of disease compared to uncomplicated pregnancies. This research supports a potential role of TLR9 activation of an innate immune response evident in preeclampsia which may possibly be initially triggered by dysfunctional mitochondria.

Item Type:	Article
Uncontrolled Keywords:	Neutrophils, Mitochondria, Placenta, Humans, Pre-Eclampsia, DNA, Mitochondrial, Cytokines, Prognosis, Case-Control Studies, Follow-Up Studies, Prospective Studies, Signal Transduction, Gestational Age, Pregnancy, Adult, Female, Toll-Like Receptor 9, Immunity, Innate
Depositing User:	Symplectic Admin
Date Deposited:	04 Dec 2019 10:38
Last Modified:	24 Feb 2023 08:56
DOI:	10.1038/s41598-019-42551-w
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3064602