Kacmaz, Aysecik, Deniz, Nahide Gulsah, Aydinli, Serdar Goksin, Sayil, Cigdem, Onay-Ucar, Evren, Mertoglu, Elif and Arda, Nazli
(2019)
Synthesis and antiproliferative evaluation of some 1,4-naphthoquinone derivatives against human cervical cancer cells.
OPEN CHEMISTRY, 17 (1).
pp. 337-345.
Abstract
<jats:title>Abstract</jats:title><jats:p>In the course of biological properties of quinone derivatives, the N(H)-, S- and S,S-substituted-1,4-naphthoquinones were synthesized by reactions of 2,3-dichloro-1,4-naphthoquinone with different amines (2-morpholinoaniline, tert-butyl 4-aminobenzoate, 4-tert-butylbenzylamine, N-(3-aminopropyl)-2-pipecoline, 2-amino-5,6-dimethylbenzothiazole, N,N'-diphenyl-p-phenylenediamine) and thiolat (sodium 2-methyl-2-propanethiolate). All new products were characterized by MS-ESI, UV-Vis, FT-IR,<jats:sup>1</jats:sup>H NMR,<jats:sup>13</jats:sup>C NMR. The antiproliferative activities of these compounds on human cervical cancer (HeLa) cells were evaluated by MTT (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromide) assay. Although all derivatives inhibited cell growth, the most active compound was 2-(tert-butylthio)-3-chloronaphthalene-1,4-dione 5 (IC<jats:sub>50</jats:sub>=10.16 μM) against the HeLa cells.</jats:p>
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Quinones, Amines, Thiols, Antiproliferative activity, HeLa cell |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 09 Dec 2019 17:13 |
| Last Modified: | 17 Mar 2024 04:47 |
| DOI: | 10.1515/chem-2019-0030 |
| Open Access URL: | https://doi.org/10.1515/chem-2019-0030 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3065631 |
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