Genetic variants in humanin nuclear isoform gene regions show no association with coronary artery disease



Eltermaa, Mall, MailiJakobson, , Utt, Meeme, Koks, Sulev ORCID: 0000-0001-6087-6643, Magi, Reedik and Starkopf, Joel
(2019) Genetic variants in humanin nuclear isoform gene regions show no association with coronary artery disease. BMC RESEARCH NOTES, 12 (1). 759-.

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Abstract

<h4>Objective</h4>Coronary artery disease contributes to noncommunicable disease deaths worldwide. In order to make preventive methods more accurate, we need to know more about the development and progress of this pathology, including the genetic aspects. Humanin is a small peptide known for its cytoprotective and anti-apoptotic properties. Our study looked for genomic associations between humanin-like nuclear isoform genes and coronary artery disease using CARDIoGRAMplusC4D Consortium data.<h4>Results</h4>Lookup from meta-analysis datasets gave single nucleotide polymorphisms in all 13 humanin-like nuclear isoform genes with the lowest P value for rs6151662 from the MTRNR2L2 gene including the 50 kb flanking region in both directions (P-value = 0.0037). Within the gene region alone the top variant was rs78083998 from the MTRNR2L13 region (meta-analysis P-value = 0.042). None of the found associations were statistically significant after correction for multiple testing. Lookup for expression trait loci in these gene regions gave no statistically significant variants.

Item Type: Article
Uncontrolled Keywords: Humanin, Humanin-like, Coronary artery disease, Association study, Peptide
Depositing User: Symplectic Admin
Date Deposited: 18 Dec 2019 09:26
Last Modified: 19 Jan 2023 00:12
DOI: 10.1186/s13104-019-4807-x
Open Access URL: https://bmcresnotes.biomedcentral.com/articles/10....
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URI: https://livrepository.liverpool.ac.uk/id/eprint/3066866