Ovarian tumors in children: how common are lesion recurrence and metachronous disease? A UK CCLG Surgeons Cancer Group nationwide study

Braungart, S, Craigie, RJ, Farrelly, P and Losty, PD ORCID: 0000-0003-0841-5879 (2020) Ovarian tumors in children: how common are lesion recurrence and metachronous disease? A UK CCLG Surgeons Cancer Group nationwide study. JOURNAL OF PEDIATRIC SURGERY, 55 (10). pp. 2026-2029.

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Abstract

<h4>Background</h4>Ovarian tumors in children are rare, mature teratoma being the most common histological entity. Robust guidelines to aid patient follow-up after resection are distinctly lacking. Although mature teratoma has a very good prognosis following complete resection, small studies have reported the occurrence of metachronous disease and recurrence to a variable degree (2.5-23% of patients). Nevertheless, there are surgeons who recommend no follow-up is required for these children after primary tumor resection. We investigated the incidence of (i) recurrence and (ii) metachronous disease in pediatric patients following ovarian tumor resection.<h4>Methods</h4>Retrospective multicenter study amongst UK pediatric surgical oncology centers. Females <16 years with diagnosis of ovarian tumor from 2006 to 2016 were included. Functional/neonatal ovarian cysts were excluded.<h4>Results</h4>Three hundred ten patients with ovarian tumors treated at 12 surgical oncology centers were identified. Mean age at surgery was 11 years [IQR 8-14]. Most common diagnosis were mature teratoma (57%, 177 cases), immature teratoma (10.9%, 34 cases) and serous cystadenoma (7.7%, 24 cases). 8.1% (25 cases) of all females were identified with tumor recurrence/ metachronous disease. 5.1% (9 cases) of patients with mature teratoma had recurrent/ metachronous disease. Most of these patients were diagnosed at routine clinic follow-up.<h4>Conclusion</h4>Our study clearly shows that ovarian tumor recurrence(s) and metachronous disease occur, even in "benign" ovarian tumors. We recommend female pediatric patients should have robust follow-up care plans after primary diagnosis and resection of ovarian tumor(s).<h4>Level of evidence statement</h4>This is a level II evidence study. It is a retrospective multicentre collaborative study which summarizes data from a national cohort of children.

Item Type:	Article
Uncontrolled Keywords:	Ovarian tumor, Ovarian teratoma, Ovary-sparing surgery, Follow-up, Pediatric, Adolescent, UK CCLG Surgeons
Depositing User:	Symplectic Admin
Date Deposited:	16 Jan 2020 08:49
Last Modified:	19 Jan 2023 00:09
DOI:	10.1016/j.jpedsurg.2019.10.059
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3070695