Vetkas, Artur, Prans, Ele, Koks, Sulev 
ORCID: 0000-0001-6087-6643, Ratsep, Tonu and Asset, Toomas
(2020)
Aneurysmal subarachnoid haemorrhage: Effect of CRHR1 genotype on mental health-related quality of life.
SCIENTIFIC REPORTS, 10 (1).
724-.
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Aneurysmal subarachnoid haemorrhage Effect of CRHR1 genotype on mental health-related quality of life.pdf - Published version Download (1MB) | Preview |
Abstract
Quality of life (QoL) disturbances are common after aneurysmal subarachnoid hemorrhage (aSAH) both in physical and mental health domains and their causes are not clearly understood. Corticotropin-releasing hormone receptor 1 (CRHR1) is involved in stress reactivity and development of mental health disturbances after negative life-events. We performed a retrospective cohort study of long-term QoL outcomes among 125 surgically treated aSAH patients (2001-2013). QoL was assessed with Short Form Health Survey (SF-36) and compared to an age and gender matched general population. Genotyping of CRHR1 single nucleotide polymorphisms was performed (Rs7209436, Rs110402, Rs242924) and their effect on QoL scores was explored. aSAH patients experienced a reduced quality of life in all domains. CRHR1 minor genotype was associated with higher SF-36 mental health (OR = 1.31-1.6, p < 0.05), role-emotional (OR = 1.57, p = 0.04) and vitality scores (OR = 1.31-1.38, p < 0.05). Association of all studied SNP's with vitality and Rs242924 with mental health scores remained statistically significant after Bonferroni correction. Mental quality of life scores were associated with physical state of patients, antidepressant history and CRHR1 genotype. Predisposition to mental health disturbances after stressful life-events might be associated with reduced mental QoL after aSAH and selected patients could be provided advanced counselling in the recovery phase.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Humans, Subarachnoid Hemorrhage, Genetic Predisposition to Disease, Receptors, Corticotropin-Releasing Hormone, Retrospective Studies, Cohort Studies, Emotions, Life Change Events, Mental Health, Mental Disorders, Genotype, Polymorphism, Single Nucleotide, Quality of Life, Vitalism, Adult, Aged, Aged, 80 and over, Middle Aged, Female, Male, Young Adult |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 04 Feb 2020 13:13 |
| Last Modified: | 19 Jan 2023 00:05 |
| DOI: | 10.1038/s41598-020-57527-4 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3073410 |
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