A systematic review and meta-analysis of the neural correlates of psychological therapies in major depression

Sankar, Anjali, Melin, Alice, Lorenzetti, Valentina ORCID: 0000-0002-5917-7068, Horton, Paul, Costafreda, Sergi G and Fu, Cynthia HY (2018) A systematic review and meta-analysis of the neural correlates of psychological therapies in major depression. PSYCHIATRY RESEARCH-NEUROIMAGING, 279. pp. 31-39.

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Official URL: http://dx.doi.org/10.1016/j.pscychresns.2018.07.00...

Abstract

Longitudinal neuroimaging studies in major depression have revealed cortico-limbic abnormalities which are modulated by treatment. We performed a systematic review and meta-analysis of psychotherapy treatment studies measuring neural function and metabolism using fMRI, PET, SPECT and MRS. Seventeen studies were included in the systematic review, total of 200 major depression participants (mean age 37.6 years), all medication free, and 116 healthy controls (mean age 36.4 years). Neuroimaging assessments were performed prior to initiation of treatment and following course of treatment. Treatment durations were: 16-30 weeks for CBT, 11 weeks for behavioral activation therapy, and up to 15 months for psychodynamic psychotherapy. The meta-analysis consisted of studies in which both groups had same serial scans and comparable tasks; total of 5 studies with visual presentation tasks of emotional stimuli: 55 patients (mean age: 38.7 years) and 55 healthy controls (mean age: 36.3 years). The meta-analysis revealed a significant group by time effect in left rostral anterior cingulate, in which patients showed increased activity following psychotherapy while healthy controls showed a decrease at follow up. Longitudinal treatment effects revealed reduced left precentral cortical activity in major depression. Findings could be indicative of improvements in emotion responsivity that may be achieved following psychotherapy.

Item Type:	Article
Uncontrolled Keywords:	Meta-analysis, Neuroimaging, Major depressive disorder, Cognitive behavioral therapy, Psychodynamic, Interpersonal, Psychotherapy, Psychological intervention
Depositing User:	Symplectic Admin
Date Deposited:	07 Feb 2020 14:12
Last Modified:	19 Jan 2023 00:03
DOI:	10.1016/j.pscychresns.2018.07.002
Open Access URL:	https://repository.uel.ac.uk/item/84758
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3073981