Li, Yan-Ming, Jiang, Chao, He, Liu, Li, Xin-Xu, Hou, Xiao-Xia, Chang, San-Shuai, Lip, Gregory YH 
ORCID: 0000-0002-7566-1626, Du, Xin, Dong, Jian-Zeng and Ma, Chang-Sheng
(2019)
Sex Differences in Presentation, Quality of Life, and Treatment in Chinese Atrial Fibrillation Patients: Insights from the China Atrial Fibrillation Registry Study.
MEDICAL SCIENCE MONITOR, 25.
pp. 8011-8018.
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Sex Differences in Presentation, Quality of Life, and Treatment in Chinese Atrial Fibrillation Patients Insights from the Ch.pdf - Published version Download (1MB) | Preview |
Abstract
<strong>BACKGROUND</strong> There is a growing recognition of sex-related disparities in atrial fibrillation (AF). However, limited data is available in Chinese AF patients. <strong>MATERIAL AND METHODS</strong> We compared symptoms, quality of life (QoL), and treatment of AF according to sex from the China AF Registry study. <strong>RESULTS</strong> We studied 14 723 patients with non-valvular AF, of whom 5645 patients (38.3%) were female. Women were older than men (67.5±10.6 <i>vs</i>. 62.2±12.2). Compared to men, women had more comorbidities and a higher proportion of CHA₂DS₂-VASC score ≥2. Women with AF experienced more severe or disabling symptoms than men (33.7% <i>vs</i>. 22.9% in age <75 group; 40.3% <i>vs</i>. 28.7% in age ≥75 group; both <i>P</i><0.0001). After multivariate analysis, women with AF still had lower QoL (OR 0.69; 95%CI, 0.63-0.76; <i>P</i><0.0001). Women tended to have lower rates of ablation and rhythm-control drug use in those aged <75 years. Oral anticoagulant use was low and had no sex difference in AF patients with a CHA₂DS₂-VASC score ≥2. <strong>CONCLUSIONS</strong> In Chinese AF patients, women were older and more symptomatic, and had worse QoL. Despite all these differences, women tended to receive less rhythm-control treatment in those aged <75 years. Oral anticoagulant was substantially underused in high stroke risk patients, regardless of sex.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Atrial Fibrillation, Quality of Life, Sex Characteristics, Therapeutics |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 14 Feb 2020 16:32 |
| Last Modified: | 19 Jan 2023 00:03 |
| DOI: | 10.12659/MSM.919366 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3075031 |
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