Thromboembolic risks associated with paroxysmal and persistent atrial fibrillation in Asian patients: a report from the Chinese atrial fibrillation registry



Wang, Ying, Ma, Chang-Sheng, Du, Xin, He, Liu, Li, Jie, Wang, Guo-Hong, Wen, Dan, Dong, Jian-Zeng, Pan, Jian-Hong and Lip, Gregory YH ORCID: 0000-0002-7566-1626
(2019) Thromboembolic risks associated with paroxysmal and persistent atrial fibrillation in Asian patients: a report from the Chinese atrial fibrillation registry. BMC CARDIOVASCULAR DISORDERS, 19 (1). 283-.

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Abstract

<h4>Background</h4>Several studies have reported on atrial fibrillation (AF) outcomes, including thromboembolism in patients with paroxysmal and non-paroxysmal AF; however the findings still remain controversial on whether risks differ between these clinical subtypes and limited data are available in Asian cohorts.<h4>Methods</h4>We compared the risk of thromboembolism between paroxysmal and persistent AF patients, in a large contemporary Chinese cohort study. A total of 8529 non-valvular atrial fibrillation (NVAF) patients from the Chinese Atrial Fibrillation Registry (CAFR) study were enrolled. The study subjects were divided into two groups: paroxysmal AF (PaAF, defined as AF lasting within 7 days, n = 4642) and persistent AF (PeAF, lasting over 7 days, n = 3887) groups.<h4>Results</h4>In non-anticoagulated patients, PeAF group demonstrated a higher risk of stroke, all-cause death, cardiac/ non-cardiac death and composition of stroke/ transient ischemic attack (TIA)/peripheral thromboembolism (PT)/all-cause death, compared to the PaAF group. No significant difference was found in anticoagulated subjects. On multivariate analysis in non-anticoagulated patients, age ≥ 75 years (P = 0.046) and prior stroke/TIA/PT (P = 0.018) but not AF type (P = 0.63) were significantly associated with the risk of stroke/TIA/PT events.<h4>Conclusions</h4>Stroke, all-cause death and cardiac/non-cardiac death in Chinese NVAF population was increased in non-anticoagulated PeAF patients compared with PaAF group, but same between anticoagulated PeAF and PaAF patients. After adjustment, AF type was not an independent predictor of thromboembolism in NVAF patients.<h4>Clinical trial registration</h4>Chinese Clinical Trial Registry ChiCTR-OCH-13003729. Registered 22 October 2013.

Item Type: Article
Uncontrolled Keywords: Atrial fibrillation, Thromboembolism, Risk factors, Stroke, Outcome
Depositing User: Symplectic Admin
Date Deposited: 17 Feb 2020 09:55
Last Modified: 23 Feb 2023 04:12
DOI: 10.1186/s12872-019-1260-7
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3075373