Keeley, Alexander J, Beeching, Nicholas J 
ORCID: 0000-0002-7019-8791, Stott, Katharine E ORCID: 0000-0001-7079-7957, Roberts, Paul, Watson, Alastair and Beadsworth, Michael J
(2016)
<i>Clostridium difficile</i>: A healthcare-associated infection of unknown significance in adults in sub-Saharan Africa.
MALAWI MEDICAL JOURNAL, 28 (2).
pp. 66-69.
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Abstract
<h4>Background</h4><i>Clostridium difficile</i> infection (CDI) causes a high burden of disease in high-resource healthcare systems, with significant morbidity, mortality, and financial implications. CDI is a healthcare-associated infection for which the primary risk factor is antibiotic usage, and it is the leading cause of bacterial diarrhoea in HIV-infected patients in the United States. Little is known about the disease burden of CDI in sub-Saharan Africa, where HIV and healthcare-associated infections are more prevalent and antibiotic usage is less restricted. This article reviews published literature on CDI in sub-Saharan Africa, highlighting areas for future research.<h4>Methods</h4>English language publications since 1995 were identified from online databases (PubMed, Medline, Google Scholar, and SCOPUS), using combinations of keywords <i>"C. difficile"</i>, "Africa", and "HIV".<h4>Results</h4>Ten relevant studies were identified. There was considerable variation in the methodologies used to assess for carriage of toxigenic <i>C. difficile</i> and its associations. Eight studies reported carriage of toxigenic <i>C. difficile</i>. Three (of three) studies found an association with antibiotic usage. One (of four) studies showed an association with HIV infection. One study showed no association with degree of immunosuppression in HIV. Two (of three) studies showed an association between carriage of toxigenic <i>C. difficile</i> and diarrhoeal illness.<h4>Conclusions</h4>While the carriage of toxigenic <i>C. difficile</i> is well described in sub-Saharan Africa, the impact of CDI in the region remains poorly understood and warrants further research.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Intestine, Large, Humans, Clostridium Infections, Cross Infection, Diarrhea, Anti-Bacterial Agents, Clostridioides difficile |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 24 Feb 2020 14:27 |
| Last Modified: | 18 Oct 2023 05:29 |
| DOI: | 10.4314/mmj.v28i2.8 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3076465 |
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