Associations among echocardiography, cardiac biomarkers, insulin metabolism, morphology, and inflammation in cats with asymptomatic hypertrophic cardiomyopathy

van Hoek, Ingrid, Hodgkiss-Geere, Hannah ORCID: 0000-0001-7561-8479, Bode, Elizabeth F ORCID: 0000-0003-3754-6026, Hamilton-Elliott, Julie, Motskula, Paul, Palermo, Valentina, Pereira, Yolanda M, Culshaw, Geoff J, Ivanova, Anna and Dukes-McEwan, Jo ORCID: 0000-0002-0326-8251 (2020) Associations among echocardiography, cardiac biomarkers, insulin metabolism, morphology, and inflammation in cats with asymptomatic hypertrophic cardiomyopathy. In: American College of Veterinary Internal Medicine Forum, 2018-6-14 - 2018-6-16, United States.

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Abstract

<h4>Background</h4>Insulin, insulin-like growth factor-1 (IGF-1), and inflammation possibly are involved in cats with asymptomatic hypertrophic cardiomyopathy (aHCM).<h4>Objectives</h4>To evaluate echocardiography, morphology, cardiac and inflammatory markers, insulin and IGF-1 in cats with aHCM.<h4>Animals</h4>Fifty-one client-owned cats with aHCM.<h4>Methods</h4>Observational descriptive study. Variables (body weight [BW], body condition score [BCS], echocardiography, and serum concentrations of N-terminal pro-B-type natriuretic peptide [NT-proBNP], ultra-sensitive troponin-I [c-TnI], serum amyloid A [SAA], insulin, glucose and IGF-1) were evaluated for significant increases above echocardiography cutoff values and laboratory reference ranges, associations and effect of left atrial (LA) remodeling and generalized hypertrophy.<h4>Results</h4>Cats with aHCM had BCS ≥6/9 (P = .01) and insulin (P < .001), NT-proBNP (P = .001) and cTn-I (P < .001) above laboratory reference ranges. Associations were present between NT-proBNP and maximum end-diastolic interventricular septum thickness (IVSd; ρ = .32; P = .05), maximum end-diastolic left ventricular free wall thickness;(ρ = .41; P = .01), LA/Aorta (ρ = .52; P = .001) and LA diameter (LA-max; ρ = .32; P = .05); c-TnI and LA/Aorta (ρ = .49; P = .003) and LA-max (ρ = .28; P = .05); and SAA and number of IVSd regions ≥6 mm thickness (ρ = .28; P = .05). Body weight and BCS were associated with IGF-1 (r = 0.44; P = .001), and insulin (ρ = .33; P = .02), glucose (ρ = .29; P = .04) and IGF-1 (ρ = .32; P = .02), respectively. Concentrations of NT-proBNP (P = .02) and c-TnI (P = .01), and SAA (P = .02), were higher in cats with LA remodeling, and generalized hypertrophy, respectively.<h4>Conclusions and clinical importance</h4>Results suggest potential implications of insulin, IGF-1, and inflammation in cats with aHCM, but it remains to be confirmed whether these findings represent a physiological process or a part of the pathogenesis and development of disease.

Item Type:	Conference or Workshop Item (Unspecified)
Uncontrolled Keywords:	cardiac hypertrophy, cat, hypertrophic obstructive cardiomyopathy, insulin, IGF-1 mediated growth
Depositing User:	Symplectic Admin
Date Deposited:	02 Mar 2020 11:43
Last Modified:	19 Jan 2023 00:01
DOI:	10.1111/jvim.15730
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3076467