Simpson, Kelly MJ, Mor, Siobhan M 
ORCID: 0000-0003-0121-2016, Ward, Michael P, Collins, Julie, Flint, James, Hill-Cawthorne, Grant A and Ghany, Moataz Abd El
(2020)
Genomic characterisation of <i>Salmonella enterica</i> serovar Wangata isolates obtained from different sources reveals low genomic diversity.
PLOS ONE, 15 (2).
e0229697-.
Abstract
Salmonella enterica serovar Wangata is an important pathogen in New South Wales (NSW), Australia. The incidence of S. Wangata is increasing and transmission is suspected to be via a non-food source. A recent outbreak investigation of sources of S. Wangata recovered isolates from humans, domestic animals, wildlife and the environment. Here, we extend that investigation by characterising and describing the genomic determinates of these isolates. We found that Australian S. Wangata isolates from different sources exhibited similar virulence and antimicrobial resistance gene profiles. There were no major genomic differences between isolates obtained from different geographical regions within Australia or from different host species. In addition, we found evidence (low number of SNPs and identical virulence gene profiles) suggestive of an international transmission event between Australia and the United Kingdom. This study supports the hypothesis that S. Wangata is shared between different hosts in NSW, Australia and provides strong justification for the continued use of genomic surveillance of Salmonella.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Animals, Humans, Salmonella enterica, Phylogeny, Genome, Bacterial, New South Wales, Genetic Variation, Serogroup, Whole Genome Sequencing |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 13 Mar 2020 10:48 |
| Last Modified: | 14 Oct 2023 20:20 |
| DOI: | 10.1371/journal.pone.0229697 |
| Open Access URL: | https://journals.plos.org/plosone/article?id=10.13... |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3078876 |
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