White blood cell differentials in dogs with congestive heart failure (CHF) in comparison to those in dogs without cardiac disease

Hamilton-Elliott, J, Ambrose, E, Christley, R ORCID: 0000-0001-9250-3032 and Dukes-McEwan, J ORCID: 0000-0002-0326-8251 (2018) White blood cell differentials in dogs with congestive heart failure (CHF) in comparison to those in dogs without cardiac disease. JOURNAL OF SMALL ANIMAL PRACTICE, 59 (6). pp. 364-372.

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Abstract

<h4>Objectives</h4>To determine if dogs with congestive heart failure have different white blood cell differential cell counts than dogs without cardiac disease.<h4>Materials and methods</h4>In total, 72 dogs with congestive heart failure and 143 controls were included in this retrospective study. Signalment, white blood cell differential counts and echocardiography data were retrieved. Basic statistical analysis was performed on white blood cell differential counts, and principal component analysis was used to compare these counts between cases and controls, with age, gender and case/control status as supplementary variables. Cases and controls were compared with binary logistic regression for the principal components identified and individual white blood cell differential counts. Principal component analysis of cases alone was conducted with age, gender, weight and mitral E wave:isovolumic relaxation time as supplementary variables. Linear regression analysis was used to explore the association between mitral E wave:isovolumic relaxation time and the principal components, weight, gender, age and diagnosis (mitral valve disease or dilated cardiomyopathy).<h4>Results</h4>Among cases and controls, the largest variance in data (component 1) was associated with neutrophils, band neutrophils, monocytes and case status (P<0·01). The odds of an individual being a case increased 2·5-fold (95% confidence interval: 1·4 to 4·4) for each unit increase in component 1. Among the cases, mitral E wave:isovolumic relaxation time was associated with neutrophil count and case/control category.<h4>Clinical significance</h4>Dogs with congestive heart failure had a statistically significant increase in neutrophils, band neutrophils and monocytes in comparison with those without cardiac disease but the cell counts remained within normal reference intervals.

Item Type:	Article
Additional Information:	Date: 2015-07-10 (submitted)
Uncontrolled Keywords:	Animals, Dogs, Cardiomyopathy, Dilated, Mitral Valve Insufficiency, Dog Diseases, Echocardiography, Leukocyte Count, Case-Control Studies, Retrospective Studies, Principal Component Analysis, Female, Male, Heart Failure
Depositing User:	Symplectic Admin
Date Deposited:	19 Mar 2020 12:09
Last Modified:	18 Jan 2023 23:57
DOI:	10.1111/jsap.12809
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3078957

Available Versions of this Item

• White blood cell differentials in dogs with congestive heart failure (CHF) in comparison to those in dogs without cardiac disease. (deposited 15 Jan 2018 12:43)
  • White blood cell differentials in dogs with congestive heart failure (CHF) in comparison to those in dogs without cardiac disease. (deposited 19 Mar 2020 12:09) [Currently Displayed]