Subthalamic nucleus deep brain stimulation for Parkinson's disease: current trends and future directions

Macerollo, Antonella ORCID: 0000-0003-4322-2706, Zrinzo, Ludvic, Akram, Harith, Foltynie, Thomas and Limousin, Patricia (2020) Subthalamic nucleus deep brain stimulation for Parkinson's disease: current trends and future directions. EXPERT REVIEW OF MEDICAL DEVICES, 17 (10). pp. 1063-1074.

Text Review STN_030220clean.docx - Author Accepted Manuscript Download (197kB)

Abstract

Over the last three decades, extensive basic and clinical research has been performed on the use of subthalamic nucleus (STN) as the preferred deep brain stimulation (DBS) target for the treatment of Parkinson's disease (PD). The mechanism underlying the benefit for the motor symptoms in PD is related to the modulation of firing patterns within the hyperdirect projections from motor cortical areas, as well as within the afferent and efferent fibers to the motor STN. Advancements in neuroimaging techniques allow us to identify precisely the STN optimizing surgical targeting. In this review, we provide an update on the current uses of STN-DBS as a routine therapy as well as its experimental indications in PD, the critical aspects associated with its successful implementation and recent advances in DBS technology.

Item Type:	Article
Uncontrolled Keywords:	Deep brain stimulation, lead technology, neurophysiology, neuroimaging side effects, subthalamic nucleus, neuroimaging, side effects
Depositing User:	Symplectic Admin
Date Deposited:	26 May 2020 08:17
Last Modified:	18 Jan 2023 23:51
DOI:	10.1080/17434440.2020.1747433
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3088728