Contingent negative variation: a biomarker of abnormal attention in functional movement disorders

Teodoro, T, Koreki, A, Meppelink, AM, Little, S, Nielsen, G, Macerollo, A ORCID: 0000-0003-4322-2706, Ferreira, JJ, Parees, I, Lang, A and Edwards, MJ (2020) Contingent negative variation: a biomarker of abnormal attention in functional movement disorders. EUROPEAN JOURNAL OF NEUROLOGY, 27 (6). pp. 985-994.

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Abstract

<h4>Background and purpose</h4>Contingent negative variation (CNV) is a negative cortical wave that precedes a pre-cued imperative stimulus requiring a quick motor response. It has been related to motor preparation and anticipatory attention. The aim was to ascertain whether the clinical improvement of functional movement disorders after physiotherapy would be associated with faster reaction times and modulation of CNV.<h4>Methods</h4>Motor performance and CNV were analysed during a pre-cued choice reaction time task with varying cue validity. Twenty-one patients with functional movement disorders and 13 healthy controls at baseline were compared. Patients then underwent physiotherapy. At follow-up after physiotherapy, patients were categorized as clinically improved (responders) or not improved (non-responders) and retested.<h4>Results</h4>At baseline, patients did not generate CNV, contrary to controls [mean amplitude (µV) at the end of preparation to move: patients -0.47 (95% CI -1.94, 1.00) versus controls -2.59 (95% CI -4.46, -0.72)]. Responders performed faster after physiotherapy [mean natural logarithm (ln) reaction time (RT) (ms): follow-up 6.112 (95% CI 5.923, 6.301) versus baseline 6.206 (95% CI 6.019, 6.394), P = 0.010], contrary to non-responders. Simultaneously, responders showed a recovery of CNV after physiotherapy [follow-up -1.95 (95% CI -3.49, -0.41) versus baseline -0.19 (95% CI -1.73, 1.35), P < 0.001], contrary to non-responders [follow-up -0.32 (95% CI -1.79, 1.14) versus baseline -0.72 (95% CI -2.19, 0.75), P = 0.381].<h4>Conclusions</h4>Clinical improvement of functional movement disorders after physiotherapy was associated with faster reaction times and normalization of CNV, which was absent at baseline. These findings suggest that CNV may constitute a useful neurophysiological biomarker related to abnormal attention in functional movement disorders.

Item Type:	Article
Uncontrolled Keywords:	biomarkers, functional neurological disorders, functional movement disorders, psychogenic disorders
Depositing User:	Symplectic Admin
Date Deposited:	01 Jun 2020 09:41
Last Modified:	18 Jan 2023 23:50
DOI:	10.1111/ene.14189
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3089193