Vitamin D in melanoma: Controversies and potential role in combination with immune check-point inhibitors


Stucci, Luigia Stefania, D'Oronzo, Stella, Tucci, Marco, Macerollo, Antonella ORCID: 0000-0003-4322-2706, Ribero, Simone, Spagnolo, Francesco, Marra, Elena, Picasso, Virginia, Orgiano, Laura, Marconcini, Riccardo et al (show 9 more authors) (2018) Vitamin D in melanoma: Controversies and potential role in combination with immune check-point inhibitors. CANCER TREATMENT REVIEWS, 69. pp. 21-28.

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Abstract

The role of vitamin D in melanoma is still controversial. Although several Authors described a correlation between vitamin D deficiency and poor survival in metastatic melanoma patients, clinical trials exploring the effects of vitamin D supplementation in this clinical setting were mostly inconclusive. However, recent evidence suggests that vitamin D exerts both anti-proliferative effects on tumor cells and immune-modulating activities, that have been widely explored in auto-immune disorders. On the one hand, vitamin D has been shown to inhibit T-helper17 lymphocytes, notoriously involved in the pathogenesis of immune-related adverse events (iAEs) which complicate immune-checkpoint inhibitor (ICI) treatment. On the other hand, vitamin D up-regulates PDL-1 expression on both epithelial and immune cells, suggesting a synergic effect in combination with ICIs, for which further investigation is needed.

Item Type: Article
Uncontrolled Keywords: Vitamin D, Melanoma, PDL-1, Immune check-point inhibitors, Immune related adverse events
Depositing User: Symplectic Admin
Date Deposited: 04 Jun 2020 09:08
Last Modified: 18 Jan 2023 23:50
DOI: 10.1016/j.ctrv.2018.05.016
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3089196
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