Associations with photoreceptor thickness measures in the UK Biobank



Chua, Sharon YL, Dhillon, Baljean, Aslam, Tariq, Balaskas, Konstantinos, Yang, Qi, Keane, Pearse A, Tufail, Adnan, Reisman, Charles, Foster, Paul J, Patel, Praveen J
et al (show 67 more authors) (2019) Associations with photoreceptor thickness measures in the UK Biobank. SCIENTIFIC REPORTS, 9 (1). 19440-.

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Abstract

Spectral-domain OCT (SD-OCT) provides high resolution images enabling identification of individual retinal layers. We included 32,923 participants aged 40-69 years old from UK Biobank. Questionnaires, physical examination, and eye examination including SD-OCT imaging were performed. SD OCT measured photoreceptor layer thickness includes photoreceptor layer thickness: inner nuclear layer-retinal pigment epithelium (INL-RPE) and the specific sublayers of the photoreceptor: inner nuclear layer-external limiting membrane (INL-ELM); external limiting membrane-inner segment outer segment (ELM-ISOS); and inner segment outer segment-retinal pigment epithelium (ISOS-RPE). In multivariate regression models, the total average INL-RPE was observed to be thinner in older aged, females, Black ethnicity, smokers, participants with higher systolic blood pressure, more negative refractive error, lower IOPcc and lower corneal hysteresis. The overall INL-ELM, ELM-ISOS and ISOS-RPE thickness was significantly associated with sex and race. Total average of INL-ELM thickness was additionally associated with age and refractive error, while ELM-ISOS was additionally associated with age, smoking status, SBP and refractive error; and ISOS-RPE was additionally associated with smoking status, IOPcc and corneal hysteresis. Hence, we found novel associations of ethnicity, smoking, systolic blood pressure, refraction, IOP<sub>cc</sub> and corneal hysteresis with photoreceptor thickness.

Item Type: Article
Uncontrolled Keywords: UK Biobank Eye and Vision Consortium, Cornea, Humans, Tomography, Optical Coherence, Age Factors, Sex Factors, Intraocular Pressure, Visual Acuity, Adult, Aged, Middle Aged, Biological Specimen Banks, Female, Male, Photoreceptor Cells, Vertebrate, Retinal Pigment Epithelium, United Kingdom
Depositing User: Symplectic Admin
Date Deposited: 08 Jun 2020 08:12
Last Modified: 01 Mar 2023 17:35
DOI: 10.1038/s41598-019-55484-1
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3089643