Abolins, Stephen, King, Elizabeth C, Lazarou, Luke, Weldon, Laura, Hughes, Louise, Drescher, Paul, Raynes, John G, Hafalla, Julius CR, Viney, Mark E and Riley, Eleanor M
(2017)
The comparative immunology of wild and laboratory mice, Mus musculus domesticus.
NATURE COMMUNICATIONS, 8 (1).
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Abstract
The laboratory mouse is the workhorse of immunology, used as a model of mammalian immune function, but how well immune responses of laboratory mice reflect those of free-living animals is unknown. Here we comprehensively characterize serological, cellular and functional immune parameters of wild mice and compare them with laboratory mice, finding that wild mouse cellular immune systems are, comparatively, in a highly activated (primed) state. Associations between immune parameters and infection suggest that high level pathogen exposure drives this activation. Moreover, wild mice have a population of highly activated myeloid cells not present in laboratory mice. By contrast, in vitro cytokine responses to pathogen-associated ligands are generally lower in cells from wild mice, probably reflecting the importance of maintaining immune homeostasis in the face of intense antigenic challenge in the wild. These data provide a comprehensive basis for validating (or not) laboratory mice as a useful and relevant immunological model system.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Spleen, Lymphocyte Subsets, Myeloid Cells, Feces, Animals, Mice, Inbred C57BL, Animals, Laboratory, Animals, Wild, Mice, Serum Amyloid P-Component, Blood Proteins, Haptoglobins, Immunoglobulin A, Immunoglobulin E, Immunoglobulin G, Cytokines, Flow Cytometry, Immunophenotyping, Lymphocyte Activation, Homeostasis |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 02 Jul 2020 07:40 |
| Last Modified: | 18 Jan 2023 23:47 |
| DOI: | 10.1038/ncomms14811 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3092429 |
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