D'Ignazio, Laura, Shakir, Dilem, Batie, Michael 
ORCID: 0000-0002-7508-6641, Muller, H Arno and Rocha, Sonia
(2020)
HIF-1beta Positively Regulates NF-kappaB Activity via Direct Control of TRAF6.
International Journal of Molecular Sciences, 21 (8).
202003.0168.v1-.
Abstract
<jats:p>NF-B signalling is crucial for cellular responses to inflammation but has also been associated with the hypoxia response. NF-B and HIF transcription factors possess an intense molecular crosstalk. Although it is known that HIF-1beta modulates NF-kappaB transcriptional response, very little is understood regarding how HIF-1beta contributes to NF-kappaB signalling. Here, we demonstrate that HIF-1beta is required for full NF-kappaB activation in cells following canonical and non-canonical stimuli. We found that HIF-1beta specifically controls TRAF6 expression in human cells but also in Drosophila melanogaster. HIF-1beta binds to the TRAF6 gene and controls its expression independently of HIF-1alpha. Furthermore, exogenous TRAF6 expression is able to rescue all of the cellular phenotypes observed in the absence of HIF-1beta. These results indicate that HIF-1beta is an important regulator of NF-kappaB with consequences for homeostasis and human disease.</jats:p>
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Genetics, 1 Underpinning research, 1.1 Normal biological development and functioning |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 13 Jul 2020 15:37 |
| Last Modified: | 15 Mar 2024 13:10 |
| DOI: | 10.20944/preprints202003.0168.v1 |
| Open Access URL: | https://doi.org/10.3390/ijms21083000 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3093882 |
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