Neumann, Helfried, Sergeev, Alexey ORCID: 0000-0003-1587-2517, Spannenberg, Anke and Beller, Matthias
(2020)
Efficient Palladium-Catalyzed Synthesis of 2-Aryl Propionic Acids.
Molecules, 25 (15).
E3421-.
Text
Molecules_2020_25_3421_Beller.pdf - Published version Download (6MB) | Preview |
Abstract
A flexible two-step, one-pot procedure was developed to synthesize 2-aryl propionic acids including the anti-inflammatory drugs naproxen and flurbiprofen. Optimal results were obtained in the presence of the novel ligand neoisopinocampheyldiphenylphosphine (NISPCPP) (9) which enabled the efficient sequential palladium-catalyzed Heck coupling of aryl bromides with ethylene and hydroxycarbonylation of the resulting styrenes to 2-aryl propionic acids. This cascade transformation leads with high regioselectivity to the desired products in good yields and avoids the need for additional purification steps.
Item Type: | Article |
---|---|
Uncontrolled Keywords: | Heck reaction, styrene, methoxycarbonylation, profene, palladium |
Depositing User: | Symplectic Admin |
Date Deposited: | 29 Jul 2020 13:22 |
Last Modified: | 18 Jan 2023 23:39 |
DOI: | 10.3390/molecules25153421 |
Related URLs: | |
URI: | https://livrepository.liverpool.ac.uk/id/eprint/3095577 |