Cooper, TJ, Woodward, BL, Alom, S and Harky, A ORCID: 0000-0001-5507-5841
(2020)
Coronavirus disease 2019 (COVID-19) outcomes in HIV/AIDS patients: a systematic review.
HIV medicine, 21 (9).
pp. 567-577.
Text
Coronavirus.pdf - Published version Download (458kB) | Preview |
Abstract
OBJECTIVES:The aim of the study was to systematically review current studies reporting on clinical outcomes in people living with HIV (PLHIV) infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). METHODS:We conducted a systematic review using the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) guidelines. A comprehensive literature search was conducted in Global Health, SCOPUS, Medline and EMBASE using pertinent key words and Medical Subject Headings (MeSH) terms relating to coronavirus disease 2019 (COVID-19) and HIV. A narrative synthesis was undertaken. Articles are summarized in relevant sections. RESULTS:Two hundred and eighty-five articles were identified after duplicates had been removed. After screening, eight studies were analysed, totalling 70 HIV-infected patients (57 without AIDS and 13 with AIDS). Three themes were identified: (1) controlled HIV infection does not appear to result in poorer COVID-19 outcomes, (2) more data are needed to determine COVID-19 outcomes in patients with AIDS and (3) HIV-infected patients presenting with COVID-19 symptoms should be investigated for superinfections. CONCLUSIONS:Our findings suggest that PLHIV with well-controlled disease are not at risk of poorer COVID-19 disease outcomes than the general population. It is not clear whether those with poorly controlled HIV disease and AIDS have poorer outcomes. Superimposed bacterial pneumonia may be a risk factor for more severe COVID-19 but further research is urgently needed to elucidate whether PLHIV are more at risk than the general population.
Item Type: | Article |
---|---|
Uncontrolled Keywords: | COVID-19, AIDS, HIV |
Depositing User: | Symplectic Admin |
Date Deposited: | 07 Aug 2020 07:06 |
Last Modified: | 18 Jan 2023 23:38 |
DOI: | 10.1111/hiv.12911 |
Related URLs: | |
URI: | https://livrepository.liverpool.ac.uk/id/eprint/3096590 |