Dairy-Inspired Coatings for Bone Implants from Whey Protein Isolate-Derived Self-Assembled Fibrils.

Rabe, Rebecca, Hempel, Ute, Martocq, Laurine, Keppler, Julia K, Aveyard, Jenny and Douglas, Timothy EL (2020) Dairy-Inspired Coatings for Bone Implants from Whey Protein Isolate-Derived Self-Assembled Fibrils. International Journal of Molecular Sciences, 21 (15). E5544-.

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Official URL: https://www.mdpi.com/1422-0067/21/15/5544

Abstract

To improve the integration of a biomaterial with surrounding tissue, its surface properties may be modified by adsorption of biomacromolecules, e.g., fibrils. Whey protein isolate (WPI), a dairy industry by-product, supports osteoblastic cell growth. WPI's main component, β-lactoglobulin, forms fibrils in acidic solutions. In this study, aiming to develop coatings for biomaterials for bone contact, substrates were coated with WPI fibrils obtained at pH 2 or 3.5. Importantly, WPI fibrils coatings withstood autoclave sterilization and appeared to promote spreading and differentiation of human bone marrow stromal cells (hBMSC). In the future, WPI fibrils coatings could facilitate immobilization of biomolecules with growth stimulating or antimicrobial properties.

Item Type:	Article
Uncontrolled Keywords:	coating, stem cell, whey protein isolate, bone, fibril
Depositing User:	Symplectic Admin
Date Deposited:	02 Sep 2020 11:14
Last Modified:	18 Jan 2023 23:35
DOI:	10.3390/ijms21155544
Open Access URL:	https://doi.org/10.3390/ijms21155544
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3099677