Multi-meridian corneal imaging of air-puff induced deformation for improved detection of biomechanical abnormalities


Curatolo, Andrea, Birkenfeld, Judith S, Martinez-Enriquez, Eduardo, Germann, James A, Muralidharan, Geethika, Palaci, Jesus, Pascual, Daniel, Eliasy, Ashkan ORCID: 0000-0002-4473-1900, Abass, Ahmed ORCID: 0000-0002-8622-4632, Solarski, Jedrzej et al (show 4 more authors) (2020) Multi-meridian corneal imaging of air-puff induced deformation for improved detection of biomechanical abnormalities. BIOMEDICAL OPTICS EXPRESS, 11 (11). pp. 6337-6355.

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Abstract

Corneal biomechanics play a fundamental role in the genesis and progression of corneal pathologies, such as keratoconus; in corneal remodeling after corneal surgery; and in affecting the measurement accuracy of glaucoma biomarkers, such as the intraocular pressure (IOP). Air-puff induced corneal deformation imaging reveals information highlighting normal and pathological corneal response to a non-contact mechanical excitation. However, current commercial systems are limited to monitoring corneal deformation only on one corneal meridian. Here, we present a novel custom-developed swept-source optical coherence tomography (SSOCT) system, coupled with a collinear air-puff excitation, capable of acquiring dynamic corneal deformation on multiple meridians. Backed by numerical simulations of corneal deformations, we propose two different scan patterns, aided by low coil impedance galvanometric scan mirrors that permit an appropriate compromise between temporal and spatial sampling of the corneal deformation profiles. We customized the air-puff module to provide an unobstructed SSOCT field of view and different peak pressures, air-puff durations, and distances to the eye. We acquired multi-meridian corneal deformation profiles (a) in healthy human eyes <i>in vivo</i>, (b) in porcine eyes <i>ex vivo</i> under varying controlled IOP, and (c) in a keratoconus-mimicking porcine eye <i>ex vivo</i>. We detected deformation asymmetries, as predicted by numerical simulations, otherwise missed on a single meridian that will substantially aid in corneal biomechanics diagnostics and pathology screening.

Item Type: Article
Uncontrolled Keywords: Bioengineering, Biomedical Imaging, Eye Disease and Disorders of Vision, 4 Detection, screening and diagnosis, 4.1 Discovery and preclinical testing of markers and technologies, Eye
Depositing User: Symplectic Admin
Date Deposited: 07 Sep 2020 08:35
Last Modified: 11 Apr 2024 17:59
DOI: 10.1364/BOE.402402
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3100123
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