Raitio, Arimatias, Salim, Adeline and Losty, Paul ORCID: 0000-0003-0841-5879
(2020)
Congenital diaphragmatic hernia—does the presence of a hernia sac improve outcome? A systematic review of published studies.
European Journal of Pediatrics, 180 (2).
pp. 333-337.
This is the latest version of this item.
Abstract
Early reports have suggested survival benefits associated with a hernia sac in congenital diaphragmatic hernia (CDH). However, these studies have included only small subsets of patients. This systematic review aimed to evaluate differences in outcomes of CDH newborns with and without a hernia sac. PubMed and Embase databases were searched using relevant key terms. Papers were independently reviewed by two authors with final selection approved by the senior author. Original search retrieved 537 papers; the final review included 8 studies (n = 837 patients). There were 168 CDH patients (20%) with a hernia sac with an overall survival of 93% vs 73% for CDH newborns without a sac (p < 0.001). Twenty-three percent of patients with a CDH sac required diaphragm patch repair vs 44% patients without a sac (p < 0.001). Pulmonary hypertension was manifested in 44% of CDH babies with a hernia sac vs 64% without a sac (p < 0.001). Three studies compared ECMO requirement: 15% with a hernia sac and 34% without sac, p < 0.001. Conclusion: This study shows significant survival benefits in newborns associated with presence of a CDH sac. This may be likely related to these infants having more favourable physiology with less severe pulmonary hypertension and/or smaller anatomical defects requiring primary closure only.
Item Type: | Article |
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Uncontrolled Keywords: | CDH, Congenital diaphragmatic hernia, ECMO, Hernia sac, Survival |
Depositing User: | Symplectic Admin |
Date Deposited: | 10 Sep 2020 08:43 |
Last Modified: | 18 Jan 2023 23:34 |
DOI: | 10.1007/s00431-020-03779-1 |
Open Access URL: | https://doi.org/10.1007/s00431-020-03779-1 |
Related URLs: | |
URI: | https://livrepository.liverpool.ac.uk/id/eprint/3100534 |
Available Versions of this Item
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Congenital diaphragmatic hernia-does the presence of a hernia sac improve outcome? A systematic review of published studies. (deposited 11 Aug 2020 07:29)
- Congenital diaphragmatic hernia—does the presence of a hernia sac improve outcome? A systematic review of published studies. (deposited 10 Sep 2020 08:43) [Currently Displayed]