Resistance to natural and synthetic gene drive systems



Price, Tom AR ORCID: 0000-0002-4394-6301, Windbichler, Nikolai, Unckless, Robert L, Sutter, Andreas, Runge, Jan‐Niklas, Ross, Perran A, Pomiankowski, Andrew, Nuckolls, Nicole L, Montchamp‐Moreau, Catherine, Mideo, Nicole
et al (show 11 more authors) (2020) Resistance to natural and synthetic gene drive systems. Journal of Evolutionary Biology, 33 (10). pp. 1345-1360.

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Abstract

Scientists are rapidly developing synthetic gene drive elements intended for release into natural populations. These are intended to control or eradicate disease vectors and pests, or to spread useful traits through wild populations for disease control or conservation purposes. However, a crucial problem for gene drives is the evolution of resistance against them, preventing their spread. Understanding the mechanisms by which populations might evolve resistance is essential for engineering effective gene drive systems. This review summarizes our current knowledge of drive resistance in both natural and synthetic gene drives. We explore how insights from naturally occurring and synthetic drive systems can be integrated to improve the design of gene drives, better predict the outcome of releases and understand genomic conflict in general.

Item Type: Article
Uncontrolled Keywords: CRISPR-Cas9, fitness costs, meiotic drive, population suppression, selfish genetic elements, sex ratio distorter, transposable element, Wolbachia
Depositing User: Symplectic Admin
Date Deposited: 29 Sep 2020 15:04
Last Modified: 15 Mar 2024 03:56
DOI: 10.1111/jeb.13693
Open Access URL: https://onlinelibrary.wiley.com/doi/full/10.1111/j...
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URI: https://livrepository.liverpool.ac.uk/id/eprint/3103005