Ottensmeier, Christian H 
ORCID: 0000-0003-3619-1657, Perry, Kate L, Harden, Elena L, Stasakova, Jana, Jenei, Veronika, Fleming, Jason ORCID: 0000-0001-7963-1224, Wood, Oliver, Woo, Jeongmin, Woelk, Christopher H, Thomas, Gareth J et al (show 1 more authors)
(2016)
Upregulated Glucose Metabolism Correlates Inversely with CD8(+) T-cell Infiltration and Survival in Squamous Cell Carcinoma.
Cancer Research, 76 (14).
pp. 4136-4148.
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Cancer%20Res-2016-Ottensmeier-0008-5472.CAN-15-3121.pdf - Author Accepted Manuscript Download (2MB) | Preview |
Abstract
Antibodies that block T-cell–regulatory checkpoints have recently emerged as a transformative approach to cancer treatment. However, the clinical efficacy of checkpoint blockade depends upon inherent tumor immunogenicity, with variation in infiltrating T cells contributing to differences in objective response rates. Here, we sought to understand the molecular correlates of tumor-infiltrating T lymphocytes (TIL) in squamous cell carcinoma (SCC), using a systems biologic approach to integrate publicly available omics datasets with histopathologic features. We provide evidence that links TIL abundance and therapeutic outcome to the regulation of tumor glycolysis by EGFR and HIF, both of which are attractive molecular targets for use in combination with immunotherapeutics.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CD8-Positive T-Lymphocytes, Lymphocytes, Tumor-Infiltrating, Animals, Mice, Inbred C57BL, Mice, Carcinoma, Squamous Cell, Head and Neck Neoplasms, Glucose, Up-Regulation, Female, Glucose Transporter Type 1, Hypoxia-Inducible Factor 1, alpha Subunit, Transcriptome, ErbB Receptors, Squamous Cell Carcinoma of Head and Neck |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 09 Oct 2020 07:56 |
| Last Modified: | 18 Jan 2023 23:29 |
| DOI: | 10.1158/0008-5472.CAN-15-3121 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3103875 |
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