Collapse authors list.
Hofer, Edith, Roshchupkin, Gennady V ORCID: 0000-0002-3403-2313, Adams, Hieab HH ORCID: 0000-0003-3687-2508, Knol, Maria J ORCID: 0000-0002-3597-1531, Lin, Honghuang ORCID: 0000-0003-3043-3942, Li, Shuo ORCID: 0000-0003-2331-2448, Zare, Habil, Ahmad, Shahzad ORCID: 0000-0002-8658-3790, Armstrong, Nicola J, Satizabal, Claudia L et al (show 90 more authors) , Bernard, Manon, Bis, Joshua C, Gillespie, Nathan A ORCID: 0000-0001-8655-2823, Luciano, Michelle ORCID: 0000-0002-7306-3008, Mishra, Aniket ORCID: 0000-0002-8141-1543, Scholz, Markus ORCID: 0000-0002-4059-1779, Teumer, Alexander ORCID: 0000-0002-8309-094X, Xia, Rui, Jian, Xueqiu, Mosley, Thomas H, Saba, Yasaman, Pirpamer, Lukas ORCID: 0000-0002-4390-9703, Seiler, Stephan, Becker, James T ORCID: 0000-0003-4425-4726, Carmichael, Owen, Rotter, Jerome I ORCID: 0000-0001-7191-1723, Psaty, Bruce M, Lopez, Oscar L, Amin, Najaf, van der Lee, Sven J, Yang, Qiong ORCID: 0000-0002-3658-1375, Himali, Jayandra J ORCID: 0000-0003-1391-9481, Maillard, Pauline, Beiser, Alexa S, DeCarli, Charles, Karama, Sherif, Lewis, Lindsay, Harris, Mat ORCID: 0000-0002-1135-4141, Bastin, Mark E, Deary, Ian J ORCID: 0000-0002-1733-263X, Veronica Witte, A ORCID: 0000-0001-9054-6688, Beyer, Frauke, Loeffler, Markus, Mather, Karen A, Schofield, Peter R ORCID: 0000-0003-2967-9662, Thalamuthu, Anbupalam, Kwok, John B, Wright, Margaret J ORCID: 0000-0001-7133-4970, Ames, David, Trollor, Julian ORCID: 0000-0002-7685-2977, Jiang, Jiyang ORCID: 0000-0002-2147-6302, Brodaty, Henry ORCID: 0000-0001-9487-6617, Wen, Wei ORCID: 0000-0003-2753-3870, Vernooij, Meike W ORCID: 0000-0003-4658-2176, Hofman, Albert, Uitterlinden, André G ORCID: 0000-0002-7276-3387, Niessen, Wiro J, Wittfeld, Katharina ORCID: 0000-0003-4383-5043, Bülow, Robin ORCID: 0000-0003-1884-5784, Völker, Uwe ORCID: 0000-0002-5689-3448, Pausova, Zdenka, Bruce Pike, G ORCID: 0000-0001-8924-683X, Maingault, Sophie, Crivello, Fabrice ORCID: 0000-0001-6950-984X, Tzourio, Christophe, Amouyel, Philippe ORCID: 0000-0001-9088-234X, Mazoyer, Bernard ORCID: 0000-0003-0970-2837, Neale, Michael C, Franz, Carol E ORCID: 0000-0002-8987-1755, Lyons, Michael J, Panizzon, Matthew S, Andreassen, Ole A ORCID: 0000-0002-4461-3568, Dale, Anders M, Logue, Mark, Grasby, Katrina L ORCID: 0000-0001-8539-0228, Jahanshad, Neda ORCID: 0000-0003-4401-8950, Painter, Jodie N ORCID: 0000-0002-4992-2458, Colodro-Conde, Lucía ORCID: 0000-0002-9004-364X, Bralten, Janita, Hibar, Derrek P, Lind, Penelope A ORCID: 0000-0002-3887-2598, Pizzagalli, Fabrizio ORCID: 0000-0003-4582-0224, Stein, Jason L ORCID: 0000-0003-4829-0513, Thompson, Paul M, Medland, Sarah E ORCID: 0000-0003-1382-380X, ENIGMA consortium, , Sachdev, Perminder S ORCID: 0000-0002-9595-3220, Kremen, William S, Wardlaw, Joanna M ORCID: 0000-0002-9812-6642, Villringer, Arno ORCID: 0000-0003-2604-2404, van Duijn, Cornelia M ORCID: 0000-0002-2374-9204, Grabe, Hans J ORCID: 0000-0003-3684-4208, Longstreth, William T, Fornage, Myriam ORCID: 0000-0003-0677-8158, Paus, Tomas, Debette, Stephanie ORCID: 0000-0001-8675-7968, Ikram, M Arfan ORCID: 0000-0003-0372-8585, Schmidt, Helena, Schmidt, Reinhold and Seshadri, Sudha ORCID: 0000-0001-6135-2622
(2020)
Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults.
Nature communications, 11 (1).
4796-.
Abstract
Cortical thickness, surface area and volumes vary with age and cognitive function, and in neurological and psychiatric diseases. Here we report heritability, genetic correlations and genome-wide associations of these cortical measures across the whole cortex, and in 34 anatomically predefined regions. Our discovery sample comprises 22,824 individuals from 20 cohorts within the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium and the UK Biobank. We identify genetic heterogeneity between cortical measures and brain regions, and 160 genome-wide significant associations pointing to wnt/β-catenin, TGF-β and sonic hedgehog pathways. There is enrichment for genes involved in anthropometric traits, hindbrain development, vascular and neurodegenerative disease and psychiatric conditions. These data are a rich resource for studies of the biological mechanisms behind cortical development and aging.
Item Type: |
Article
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Uncontrolled Keywords: |
ENIGMA consortium, Brain, Chromosome Structures, Humans, Neurodegenerative Diseases, Cognition, Mental Disorders, Genomics, Aging, Phenotype, Polymorphism, Single Nucleotide, Adult, Aged, Aged, 80 and over, Middle Aged, Female, Male, Genome-Wide Association Study |
Depositing User: |
Symplectic Admin
|
Date Deposited: |
12 Oct 2020 08:06 |
Last Modified: |
18 Jan 2023 23:29 |
DOI: |
10.1038/s41467-020-18367-y |
Related URLs: |
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URI: |
https://livrepository.liverpool.ac.uk/id/eprint/3104006 |