Almarzouki, Abeer, Wilson, Duncan, Ambler, Gareth, Shakeshaft, Clare, Cohen, Hannah, Yousry, Tarek, Salman, Rustam Al-Shahi, Lip, Gregory YH 
ORCID: 0000-0002-7566-1626, Houlden, Henry, Brown, Martin M et al (show 3 more authors)
(2020)
Sensitivity and specificity of blood-fluid levels for oral anticoagulant-associated intracerebral haemorrhage.
SCIENTIFIC REPORTS, 10 (1).
15529-.
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Sensitivity and specificity of blood-fluid levels for oral anticoagulant-associated intracerebral haemorrhage.pdf - Published version Download (1MB) | Preview |
Abstract
Intracerebral haemorrhage (ICH) is a life-threatening emergency, the incidence of which has increased in part due to an increase in the use of oral anticoagulants. A blood-fluid level within the haematoma, as revealed by computed tomography (CT), has been suggested as a marker for oral anticoagulant-associated ICH (OAC-ICH), but the diagnostic specificity and prognostic value of this finding remains unclear. In 855 patients with CT-confirmed acute ICH scanned within 48 h of symptom onset, we investigated the sensitivity and specificity of the presence of a CT-defined blood-fluid level (rated blinded to anticoagulant status) for identifying concomitant anticoagulant use. We also investigated the association of the presence of a blood-fluid level with six-month case fatality. Eighteen patients (2.1%) had a blood-fluid level identified on CT; of those with a blood-fluid level, 15 (83.3%) were taking anticoagulants. The specificity of blood-fluid level for OAC-ICH was 99.4%; the sensitivity was 4.2%. We could not detect an association between the presence of a blood-fluid level and an increased risk of death at six months (OR = 1.21, 95% CI 0.28-3.88, p = 0.769). The presence of a blood-fluid level should alert clinicians to the possibility of OAC-ICH, but absence of a blood-fluid level is not useful in excluding OAC-ICH.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Humans, Cerebral Hemorrhage, Anticoagulants, Tomography, X-Ray Computed, Prognosis, Administration, Oral, Sensitivity and Specificity, Aged, Aged, 80 and over, Male, Neuroimaging |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 15 Oct 2020 15:50 |
| Last Modified: | 18 Jan 2023 23:28 |
| DOI: | 10.1038/s41598-020-72504-7 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3104289 |
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