Wang, Gang-Wei, Sokolova, Olga O, Young, Tom A, Christodoulou, Ektor MS, Butts, Craig P and Bower, John F ORCID: 0000-0002-7551-8221
(2020)
Carbonylative C-C Bond Activation of Aminocyclopropanes Using a Temporary Directing Group Strategy.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 142 (45).
pp. 19006-19011.
Text
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Abstract
Temporary directing groups (TDGs) underpin a range of C-C bond activation methodologies; however, the use of TDGs for the regiocontrolled activation of cyclopropane C-C bonds is underdeveloped. In this report, we show how an unusual ring contraction process can be harnessed for TDG-based carbonylative C-C bond activations of cyclopropanes. The method involves the transient installation of an isocyanate-derived TDG, rather than relying on carbonyl condensation events as used in previous TDG-enabled C-C bond activations.
Item Type: | Article |
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Depositing User: | Symplectic Admin |
Date Deposited: | 21 Oct 2020 08:40 |
Last Modified: | 18 Jan 2023 23:26 |
DOI: | 10.1021/jacs.0c08973 |
Related URLs: | |
URI: | https://livrepository.liverpool.ac.uk/id/eprint/3104771 |