Gibson, Andrew, Hammond, Sean, Jaruthamsophon, Kanoot ORCID: 0000-0003-1563-0024, Roth, Sharin, Mosedale, Merrie and Naisbitt, Dean J
(2020)
Tolvaptan- and Tolvaptan-Metabolite-Responsive T Cells in Patients with Drug-Induced Liver Injury.
CHEMICAL RESEARCH IN TOXICOLOGY, 33 (11).
pp. 2745-2748.
Abstract
Tolvaptan is an effective drug for the treatment of autosomal dominant polycystic kidney disease, but its use is associated with a significant risk of liver injury in a small number of patients. Herein we describe the presence of tolvaptan- and tolvaptan-metabolite-responsive T cell clones within the peripheral circulation of patients with liver injury. Drug treatment of the clones resulted in a proliferative response and secretion of IFN-γ, IL-13, and the cytolytic molecule granzyme B. Future work should explore pathways of tolvaptan driven T cell activation and the role of T cells in the disease pathogenesis.
Item Type: | Article |
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Uncontrolled Keywords: | T-Lymphocytes, Humans, Cell Proliferation, Molecular Structure, Adult, Middle Aged, Female, Male, Chemical and Drug Induced Liver Injury, Tolvaptan |
Depositing User: | Symplectic Admin |
Date Deposited: | 04 Nov 2020 14:49 |
Last Modified: | 18 Jan 2023 23:23 |
DOI: | 10.1021/acs.chemrestox.0c00328 |
Open Access URL: | https://doi.org/10.1021/acs.chemrestox.0c00328 |
Related URLs: | |
URI: | https://livrepository.liverpool.ac.uk/id/eprint/3106043 |