<i>Justicia flava</i> leaf extract potently relaxes pregnant human myometrial contractility: a lead plant for drug discovery of new tocolytic drugs



Bafor, Enitome E, Prendergast, Clodagh ORCID: 0000-0002-7678-7693 and Wray, Susan ORCID: 0000-0002-0086-1359
(2020) <i>Justicia flava</i> leaf extract potently relaxes pregnant human myometrial contractility: a lead plant for drug discovery of new tocolytic drugs. EXPERIMENTAL PHYSIOLOGY, 105 (12). pp. 2033-2037.

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Abstract

<h4>New findings</h4>What is the central question of this study? Can Justicia flava leaf extract (JF) inhibit human myometrial contractility as was previously shown in mouse myometrium? What is the main finding and its importance? JF abolished human myometrial contractions and therefore presents as a lead plant in drug discovery studies involving drugs for preterm birth.<h4>Abstract</h4>In the search for new potent therapies for preterm labour, Justicia flava leaf extract (JF) was previously shown to potently inhibit uterine contractility in both pregnant and non-pregnant mouse uterus. This study took the investigation a step further and investigated the activity of JF on pregnant human myometrial contractility. JF potently inhibited human myometrial contractility in a concentration-dependent manner. This pilot study provides evidence that JF should be further investigated as a lead plant in the drug discovery of new uterine relaxants.

Item Type: Article
Uncontrolled Keywords: Acanthaceae, extract, human uterus, justicia flava, myometrium, plant, preterm birth, preterm labour, spontaneous contraction, tocolytic, uterus
Depositing User: Symplectic Admin
Date Deposited: 05 Nov 2020 15:56
Last Modified: 06 Oct 2023 05:02
DOI: 10.1113/EP088819
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3106101