Daly, Anne, Evans, Sharon, Pinto, Alex, Jackson, Richard, Ashmore, Catherine, Rocha, Julio Cesar and MacDonald, Anita
(2020)
Preliminary Investigation to Review If a Glycomacropeptide Compared to L-Amino Acid Protein Substitute Alters the Pre- and Postprandial Amino Acid Profile in Children with Phenylketonuria.
NUTRIENTS, 12 (8).
E2443-.
Abstract
In Phenylketonuria (PKU), the peptide structure of the protein substitute (PS), casein glycomacropeptide (CGMP), is supplemented with amino acids (CGMP-AA). CGMP may slow the rate of amino acid (AA) absorption compared with traditional phenylalanine-free amino acids (Phe-free AA), which may improve nitrogen utilization, decrease urea production, and alter insulin response.<h4>Aim</h4>In children with PKU, to compare pre and postprandial AA concentrations when taking one of three PS's: Phe-free AA, CGMP-AA 1 or 2.<h4>Methods</h4>43 children (24 boys, 19 girls), median age 9 years (range 5-16 years) were studied; 11 took CGMP-AA1, 18 CGMP-AA2, and 14 Phe-free AA. Early morning fasting pre and 2 h postprandial blood samples were collected for quantitative AA on one occasion. A breakfast with allocated 20 g protein equivalent from PS was given post fasting blood sample.<h4>Results</h4>There was a significant increase in postprandial AA for all individual AAs with all three PS. Postprandial AA histidine (<i>p</i> < 0.001), leucine (<i>p</i> < 0.001), and tyrosine (<i>p</i> < 0.001) were higher in CGMP-AA2 than CGMP-AA1, and leucine (<i>p</i> < 0.001), threonine (<i>p</i> < 0.001), and tyrosine (<i>p</i> = 0.003) higher in GCMP-AA2 than Phe-free AA. This was reflective of the AA composition of the three different PS's.<h4>Conclusions</h4>In PKU, the AA composition of CGMP-AA influences 2 h postprandial AA composition, suggesting that a PS derived from CGMP-AA may be absorbed similarly to Phe-free AA, but this requires further investigation.
Item Type: | Article |
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Uncontrolled Keywords: | phenylketonuria, PKU, glycomacropeptide, amino acid, absorption |
Depositing User: | Symplectic Admin |
Date Deposited: | 09 Nov 2020 10:30 |
Last Modified: | 27 Nov 2023 20:36 |
DOI: | 10.3390/nu12082443 |
Open Access URL: | https://doi.org/10.3390/nu12082443 |
Related URLs: | |
URI: | https://livrepository.liverpool.ac.uk/id/eprint/3106352 |