Leitner, Alexander, Bonvin, Alexandre MJJ, Borchers, Christoph H, Chalkley, Robert J, Chamot-Rooke, Julia, Combe, Colin W, Cox, Juergen, Dong, Meng-Qiu, Fischer, Lutz, Gotze, Michael et al (show 26 more authors)
(2020)
Toward Increased Reliability, Transparency, and Accessibility in Cross-linking Mass Spectrometry.
STRUCTURE, 28 (11).
pp. 1259-1268.
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Abstract
Cross-linking mass spectrometry (MS) has substantially matured as a method over the past 2 decades through parallel development in multiple labs, demonstrating its applicability to protein structure determination, conformation analysis, and mapping protein interactions in complex mixtures. Cross-linking MS has become a much-appreciated and routinely applied tool, especially in structural biology. Therefore, it is timely that the community commits to the development of methodological and reporting standards. This white paper builds on an open process comprising a number of events at community conferences since 2015 and identifies aspects of Cross-linking MS for which guidelines should be developed as part of a Cross-linking MS standards initiative.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Humans, Proteins, Cross-Linking Reagents, Reproducibility of Results, Protein Interaction Mapping, Proteomics, Protein Conformation, International Cooperation, Mass Spectrometry, Guidelines as Topic |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 12 Nov 2020 09:06 |
| Last Modified: | 09 May 2023 14:22 |
| DOI: | 10.1016/j.str.2020.09.011 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3106596 |
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