Heteropoly acid catalysts in Prins cyclization for the synthesis of Florol®

de Meireles, Augusto LP, da Silva Rocha, Kelly A, Kozhevnikova, Elena F, Kozhevnikov, Ivan V ORCID: 0000-0003-2453-5256 and Gusevskaya, Elena V (2021) Heteropoly acid catalysts in Prins cyclization for the synthesis of Florol®. Molecular Catalysis, 502. p. 111382.

Text manuscript revised 2 21.12.20.docx - Author Accepted Manuscript Download (290kB)

Abstract

H3PW12O40 heteropoly acid supported on SiO2 and its bulk acidic cesium salt Cs2.5H0.5PW12O40 are demonstrated to be highly active and recyclable solid catalysts for Prins cyclization allowing for the clean, high-yielding synthesis of Florol® from isoprenol and isovaleraldehyde. Florol®, a valuable floral odorant employed in a vast variety of commercial products, was obtained in ca. 80 % yield under nearly ambient conditions. Dimethylcarbonate or diethylcarbonate used as green reaction media, low catalyst loadings and moderate conditions are important features that contribute for the sustainability of the method.

Item Type:	Article
Uncontrolled Keywords:	Acid catalysis, Prins cyclization, Heteropoly acids, Florol?
Depositing User:	Symplectic Admin
Date Deposited:	03 Feb 2021 10:59
Last Modified:	18 Jan 2023 23:01
DOI:	10.1016/j.mcat.2020.111382
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3115157