Camacho-Barcia, Lucia, Garcia-Gavilan, Jesus, Papandreou, Christopher, Hansen, Thea T, Harrold, Jo A 
ORCID: 0000-0002-0899-4586, Finlayson, Graham, Blundell, John E, Sjodin, Anders, Halford, Jason CG ORCID: 0000-0003-1629-3189 and Bullo, Monica
(2021)
Circulating Metabolites Associated with Postprandial Satiety in Overweight/Obese Participants: The SATIN Study.
NUTRIENTS, 13 (2).
549-.
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Circulating Metabolites Associated with Postprandial Satiety in OverweightObese Participants The SATIN Study.pdf - Published version Download (901kB) | Preview |
Abstract
<b>Scope</b>: To identify a metabolomic profile related to postprandial satiety sensations involved in appetite control would help for a better understanding of the regulation of food intake. Methods and Results: A cross-sectional analysis of plasma metabolites was conducted over 151 overweight/obese adults from the "Satiety Innovation"-SATIN study, a randomized clinical trial of a 12-week weight-loss maintenance period. Postprandial satiety sensations (3 h-iAUC) were assessed by visual analogue scale (VAS) at the beginning and at the end of the study. Fasting plasma metabolites were profiled using a targeted multiplatform metabolomics approach before each appetite test meal. Associations between 124 metabolites and iAUC-satiety were assessed using elastic net linear regression analyses. The accuracy of the multimetabolite weighted models for iAUC-VAS was evaluated using a 10-fold cross-validation (CV) approach and the Pearson's correlation coefficients were estimated. Five and three metabolites were selected in the first and the second assessments, respectively. Circulating glycine and linoleic acid concentrations were consistently and positively associated with higher iAUC-satiety in both visits. Sucrose and sphingomyelins (C32:2, C38:1) were negatively associated with iAUC-satiety in the first visit. The Pearson correlations coefficients between the metabolomic profiles and iAUC-satiety in the first and the second appetite assessments were 0.37 and 0.27, respectively. Conclusion: Higher glycine and linoleic acid were moderately but consistently associated with higher postprandial satiety in two different appetite assessments in overweight and obese subjects.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | metabolomics, obesity, satiety |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Population Health |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 12 Apr 2021 08:17 |
| Last Modified: | 08 Feb 2024 21:54 |
| DOI: | 10.3390/nu13020549 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3118884 |
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