Carvalho, Ana L and Hedrich, Christian M 
ORCID: 0000-0002-1295-6179
(2021)
The Molecular Pathophysiology of Psoriatic Arthritis-The Complex Interplay Between Genetic Predisposition, Epigenetics Factors, and the Microbiome.
FRONTIERS IN MOLECULAR BIOSCIENCES, 8.
662047-.
Abstract
Psoriasis is a symmetric autoimmune/inflammatory disease that primarily affects the skin. In a significant proportion of cases, it is accompanied by arthritis that can affect any joint, the spine, and/or include enthesitis. Psoriasis and psoriatic arthritis are multifactor disorders characterized by aberrant immune responses in genetically susceptible individuals in the presence of additional (environmental) factors, including changes in microbiota and/or epigenetic marks. Epigenetic changes can be heritable or acquired (e.g., through changes in diet/microbiota or as a response to therapeutics) and, together with genetic factors, contribute to disease expression. In psoriasis, epigenetic alterations are mainly related to cell proliferation, cytokine signaling and microbial tolerance. Understanding the complex interplay between heritable and acquired pathomechanistic factors contributing to the development and maintenance of psoriasis is crucial for the identification and validation of diagnostic and predictive biomarkers, and the introduction of individualized effective and tolerable new treatments. This review summarizes the current understanding of immune activation, genetic, and environmental factors that contribute to the pathogenesis of psoriatic arthritis. Particular focus is on the interactions between these factors to propose a multifactorial disease model.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | psoriasis, psoriatic arthritis, environment, epigenetic, chromatin, nucleosome, inflammation, microbiota |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 22 Apr 2021 09:47 |
| Last Modified: | 18 Jan 2023 22:51 |
| DOI: | 10.3389/fmolb.2021.662047 |
| Open Access URL: | https://doi.org/10.3389/fmolb.2021.662047 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3120159 |
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