The Role of Deubiquitinases in Invasive Migration and Epithelial Integrity in Drosophila



Badmos, Hammed
(2021) The Role of Deubiquitinases in Invasive Migration and Epithelial Integrity in Drosophila. PhD thesis, University of Liverpool.

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Abstract

Cell migration and epithelial maturation are central to normal development, whilst aberrant migration or loss of epithelial integrity are involved in a number of human diseases, including cancer and birth defects. We are studying these processes in the harmless fruit fly, Drosophila melanogaster, which has been intensively studied for century because of its many attractive features for genetic research. Importantly, Drosophila has proven to be a powerful system in which to identify novel molecules that are involved in both development and diseases. We have identified genes required for cell invasion and the maintenance of epithelial integrity that are conserved from Drosophila to humans. We have uncovered novel roles of these genes which may help guide studies in more complex organisms.

Item Type: Thesis (PhD)
Uncontrolled Keywords: Drosophila, Deubiquitinases, Cell migration, Epithelial integrity, SAGA complex
Divisions: Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology
Depositing User: Symplectic Admin
Date Deposited: 10 Sep 2021 09:05
Last Modified: 18 Jan 2023 22:50
DOI: 10.17638/03120524
Supervisors:
  • Bennett, Daimark
URI: https://livrepository.liverpool.ac.uk/id/eprint/3120524